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SGC-GAK-1

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Purity:99.74%

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COA HPLC HNMR

SGC-GAK-1

Catalog No. T5169Cas No. 2226517-76-4

SGC-GAK-1 is a selective cyclin G-associated kinase (GAK) inhibitor (Ki: 3.1 nM).

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Pack Size	Price	Availability
1 mg	$31	In Stock
5 mg	$72	In Stock
10 mg	$122	In Stock
25 mg	$247	In Stock
50 mg	$397	In Stock
100 mg	$589	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock

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Product Introduction

Bioactivity

Description	SGC-GAK-1 is a selective cyclin G-associated kinase (GAK) inhibitor (Ki: 3.1 nM).
In vitro	SGC-GAK-1 potently binds GAK (Ki: 3.1 nM; Kd: 1.9 nM). SGC-GAK-1 showed strong growth inhibition in LNCaP, VCaP, and 22Rv1 cells at 10 μM, but the minimal effect in PC3 and DU145 cells. In dose-response SGC-GAK-1 showed potent antiproliferative activity in LNCaP and 22Rv1 cells at a similar dose range that it engages GAK.

Chemical Properties

Molecular Weight	389.24
Formula	C18H17BrN2O3
Cas No.	2226517-76-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 15 mg/mL

DMSO: 55 mg/mL (141.3 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5691 mL	12.8455 mL	25.6911 mL	128.4555 mL
5 mM	0.5138 mL	2.5691 mL	5.1382 mL	25.6911 mL
10 mM	0.2569 mL	1.2846 mL	2.5691 mL	12.8455 mL
20 mM	0.1285 mL	0.6423 mL	1.2846 mL	6.4228 mL
50 mM	0.0514 mL	0.2569 mL	0.5138 mL	2.5691 mL
100 mM	0.0257 mL	0.1285 mL	0.2569 mL	1.2846 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc