Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SR-318 potently inhibits the TNF-α release in whole blood (IC50 = 283 nM). SR-318 is a potent and highly selective inhibitor of p38 MAPK. The IC50 values are 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 38.00 | |
2 mg | In stock | $ 54.00 | |
5 mg | In stock | $ 89.00 | |
10 mg | In stock | $ 147.00 | |
25 mg | In stock | $ 297.00 | |
50 mg | In stock | $ 478.00 | |
100 mg | In stock | $ 689.00 | |
500 mg | In stock | $ 1,480.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 89.00 |
Description | SR-318 potently inhibits the TNF-α release in whole blood (IC50 = 283 nM). SR-318 is a potent and highly selective inhibitor of p38 MAPK. The IC50 values are 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively. |
Targets&IC50 | p38β:32 nM, p38α/β:6.11 μM, TNF-α:283 nM, p38α:5 nM |
In vitro | SR-318 presents a potent and selective type-II p38α/β inhibitor,It is used as a chemical probe for targeting this particular inactive state of these two p38 isoforms. |
Molecular Weight | 459.58 |
Formula | C27H33N5O2 |
CAS No. | 2413286-32-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (271.99 mM)
You can also refer to dose conversion for different animals. More
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SR-318 2413286-32-3 Apoptosis MAPK p38 MAPK TNF anti-inflammatory TNFR anti-cancer Inhibitor SR 318 SR318 inhibit whole TNF Receptor p38α/β Tumor Necrosis Factor Receptor blood inhibitor