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SR17018

Catalog No. T4407   CAS 2134602-45-0

SR17018 is an mu-opioid-receptor (MOR) agonist, binding with GTPγS, with an EC50 of 97 nM.

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SR17018 Chemical Structure
SR17018, CAS 2134602-45-0
Pack Size Availability Price/USD Quantity
5 mg In stock $ 64.00
10 mg In stock $ 97.00
25 mg In stock $ 213.00
50 mg In stock $ 347.00
100 mg In stock $ 563.00
200 mg In stock $ 786.00
1 mL * 10 mM (in DMSO) In stock $ 70.00
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Purity: 99.73%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description SR17018 is an mu-opioid-receptor (MOR) agonist, binding with GTPγS, with an EC50 of 97 nM.
Targets&IC50 MOR:NA
In vitro SR17018 is an mu-opioid-receptor (MOR) agonist, binding with GTPγS, with an EC50 of 97 nM. SR17018 shows no obvious effect on inducing βarrestin2 recruitment to the MOR at below 10 μM. SR17018 promotes signaling through G proteins or βarrestin2
Molecular Weight 410.72
Formula C19H18Cl3N3O
CAS No. 2134602-45-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.11 mg/mL (10 mM), Sonification/heating is recommended.

TargetMolReferences and Literature

1. Schmid CL,etal.Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.Cell. 2017 Nov 16;171(5):1165-1175.

TargetMolCitations

1. Zhuang Y, Wang Y, He B, et al. Molecular recognition of morphine and fentanyl by the human μ-opioid receptor. Cell. 2022, 185(23): 4361-4375. e19.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max Neuronal Signaling Compound Library Bioactive Compound Library GPCR Compound Library Endocrinology-Hormone Compound Library Anti-Neurodegenerative Disease Compound Library Neurotransmitter Receptor Compound Library Target-Focused Phenotypic Screening Library Anti-Parkinson's Disease Compound Library NO PAINS Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SR17018 2134602-45-0 Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor SR 17018 SR-17018 inhibit Inhibitor inhibitor

 

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