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SYP-5

Catalog No. T13050 CAS 1384268-04-5

Synonyms: SYP-5, Inhibitor, HIFs, Hypoxia-inducible factors, SYP5, inhibit, HIF-PH, SYP 5, HIF/HIF Prolyl-Hydroxylase

SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.

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SYP-5, CAS 1384268-04-5

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Purity: 98%

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Description

SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.

In vitro

A novel HIF-1 inhibitor SYP-5 was first observed by the luciferase reporter assay.?Western blots results showed SYP-5 inhibited hypoxia-induced upregulation of HIF-1.?Moreover, the proteins of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP)-2 that are targets of HIF-1, were down-regulated by SYP-5.?Furthermore, in the tube formation assay, SYP-5 suppressed angiogenesis induced by hypoxia and VEGF in vitro.?Additionally, using Transwell and RTCA assays, we found that SYP-5 also retarded the Hep3B and Bcap37 cells migration and invasion induced by hypoxia and FBS.?Detected the upstream pathways related to HIF-1 and found both PI3K/AKT and MAPK/ERK were involved in the SYP-5 mediated invasive inhibition of Bcap37 cells.?SYP-5 inhibits tumor cell migration and invasion, as well as tumor angiogenesis, which are mediated by suppressing PI3K/AKT- and MAPK/ERK-dependent HIF-1 pathway.?It suggests that SYP-5 might be a potential HIF-1 inhibitor as an anticancer agent.

Synonyms	SYP-5, Inhibitor, HIFs, Hypoxia-inducible factors, SYP5, inhibit, HIF-PH, SYP 5, HIF/HIF Prolyl-Hydroxylase
Molecular Weight	312.38
Formula	C18H16O3S
CAS No.	1384268-04-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 33.33 mg/mL (106.70 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Wang LH, et al. SYP-5, a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis. Eur J Pharmacol. 2016 Nov 15;791:560-568.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library HIF-1 Signaling Pathway Compound Library Glycometabolism Compound Library Anti-Pancreatic Cancer Compound Library Inhibitor Library Covalent Inhibitor Library Anti-Cancer Active Compound Library Epigenetics Compound Library Angiogenesis related Compound Library Bioactive Compound Library

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