Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. It also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. It suppresses the survival of Y cells and Y stem cells by triggering cell senescence and inhibiting glycolysis. It exhibits antitumor effects in multiple animal models and Y cell lines.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 30.00 | |
2 mg | In stock | $ 42.00 | |
5 mg | In stock | $ 68.00 | |
10 mg | In stock | $ 108.00 | |
25 mg | In stock | $ 197.00 | |
50 mg | In stock | $ 347.00 | |
100 mg | In stock | $ 588.00 | |
500 mg | In stock | $ 1,230.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 76.00 |
Description | SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. It also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. It suppresses the survival of Y cells and Y stem cells by triggering cell senescence and inhibiting glycolysis. It exhibits antitumor effects in multiple animal models and Y cell lines. |
Molecular Weight | 420.52 |
Formula | C24H24N2O3S |
CAS No. | 222716-34-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1eq. HCl: 20 mM
DMSO: 5 mM, Heating is recommended.
You can also refer to dose conversion for different animals. More
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SZL P1-41 222716-34-9 Apoptosis Others Ubiquitination E1/E2/E3 Enzyme E1 activating enzyme Ubiquitin ligase E2 conjugating enzyme Ubiquitin conjugating enzyme E3 ligating enzyme Inhibitor Ubiquitin activating enzyme SZL P-1-41 SZL P141 SZL P1 41 inhibit inhibitor