Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | In stock | $ 50.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 45.00 |
Description | Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects. |
In vitro | Sophocarpine exerts anti-cachectic effects by inhibiting TNF-α and IL-6 production in both RAW264.7 cells and murine primary macrophages. [1] Sophocarpine also shows antivirus activity by inhibiting HHV-6 replication in Molt-3 cells. [2] In addition, Sophocarpine is a potent blocker of HERG K+ channels with an IC50 of about 200 mM. [3] |
In vivo | Administration of 50 mg/kg/d sophocarpine for 5 days from the onset of cachexia does not inhibit the tumor growth but results in attenuation of cachexia symptoms in colon26 adenocarcinoma xenograft BALB/c mice. [1] LD50: Mice 63.94 mg/kg (i.v.) [4] |
Source |
Synonyms | Sophocarpine |
Molecular Weight | 246.35 |
Formula | C15H22N2O |
CAS No. | 145572-44-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 196.7 mM
You can also refer to dose conversion for different animals. More
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Sophocarpine monohydrate 145572-44-7 Apoptosis Autophagy Chromatin/Epigenetic Cytoskeletal Signaling Microbiology/Virology PI3K/Akt/mTOR signaling Influenza Virus AMPK Akt PI3K Inhibitor Protein kinase B Sophocarpine Monohydrate Phosphoinositide 3-kinase inhibit Sophocarpine PKB inhibitor