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Strictosamide

Catalog No. TN2239   CAS 23141-25-5

Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain.

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Strictosamide Chemical Structure
Strictosamide, CAS 23141-25-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 57.00
5 mg In stock $ 128.00
10 mg In stock $ 190.00
25 mg In stock $ 318.00
50 mg In stock $ 469.00
100 mg In stock $ 689.00
1 mL * 10 mM (in DMSO) In stock $ 140.00
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Purity: 100%
Purity: 99.5%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain.
In vitro At 20 and 40 mg/kg, strictosamide obviously decreased the TPA-induced mice ear edema (24.7 and 28.1% inhibition, respectively), and significantly inhibited acetic acid-stimulated peritoneal vascular permeability in mice (23.3 and 33.4% inhibition, respectively).?It also significantly decreased the leukocytes in the mice peritoneal cavity induced by CMC-Na at all the tested doses (46.0, 49.1, and 58.7% inhibition, respectively).?To acetic acid-induced writhing test in mice, strictosamide markedly prolonged the pain latency at 20 and 40 mg/kg and decreased the writhing counts at 40 mg/kg (49.7% inhibition).?However, it did not obviously improve the pain threshold of mice in hot-plate test[2].
Source
Molecular Weight 498.52
Formula C26H30N2O8
CAS No. 23141-25-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (45.13 mM)

TargetMolReferences and Literature

1. Synthesis and Biological Evaluation of Strictosamide Derivatives with Improved Antiviral and Antiproliferative Activities.Chem Biol Drug Des. 2015 Oct;86(4):523-30. 2. Li N , Cao L , Cheng Y , et al. In vivo anti-inflammatory and analgesic activities of strictosamide from Nauclea officinalis[J]. Pharmaceutical Biology, 2014, 52(11):1445-50.

Related compound libraries

This product is contained In the following compound libraries:
Antiparasitic Natural Product Library Anti-Parasitic Compound Library Natural Product Library Anti-Viral Compound Library RO5 Drug-like Natural Product Library Potassium Channel Blocker Library The Yao nationality medicine Library Chinese Pharmacopoeia Natural Product Library Anti-virus Traditional Chinese Medicine Monomer Library Antibiotics Library

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Keywords

Strictosamide 23141-25-5 Membrane transporter/Ion channel Microbiology/Virology Sodium Channel Parasite Antifungal ATPase Potassium Channel pain antifungal Anti-inflammatory inhibit Inhibitor antiplasmodial Fungal inhibitor

 

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