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TAK-779

Catalog No. T7499 CAS 229005-80-5

Synonyms: Takeda 779

TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

TAK-779, CAS 229005-80-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 38.00
5 mg	In stock	$ 89.00
10 mg	In stock	$ 139.00
25 mg	In stock	$ 253.00
50 mg	In stock	$ 428.00
100 mg	In stock	$ 639.00
1 mL * 10 mM (in DMSO)	In stock	$ 97.00

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Purity: 99.58%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).
Targets&IC50	MIP-1α-CCR5:1 nM (in CHO/CCR5 cells), R5 HIV-1 (Ba-L):1.2 nM (EC50, in MAGI-CCR5 cells), R5 HIV-1 (Ba-L):3.7 nM (EC50, in PBMCs), MCP-1-CCR2b:27 nM (in CHO/CCR5 cells), MIP-1β-CCR5:1 nM (in CHO/CCR5 cells), R5 HIV-1 (KK):1.6 nM (EC50, in PBMCs), RANTES-CCR5:1.4 nM (in CHO/CCR5 cells)
In vitro	TAK-779 (250 mg/animal per day) inhibits ovalbumin-induced increases in CCR5, CXCR3, IFN-γ, and TNF-α expression in mouse lung, as well as the number of total cells, lymphocytes, and eosinophils in bronchoalveolar lavage fluid (BALF), in a mouse model of asthma[1].
In vivo	TAK-779 increases intestinal allograft survival in a rat model of small intestine transplantation when administered at a dose of 10 mg/kg per day[2].

Synonyms	Takeda 779
Molecular Weight	531.13
Formula	C33H39ClN2O2
CAS No.	229005-80-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 16.66 mg/mL (31.37 mM)

DMSO: 25 mg/mL (47.07 mM)

References and Literature

1. Suzaki Y , Hamada K , Nomi T , et al. A small-molecule compound targeting CCR5 and CXCR3 prevents airway hyperresponsiveness and inflammation[J]. European Respiratory Journal, 2008, 31(4):783-789. 2. Takama Y , Miyagawa S , Yamamoto A , et al. Effects of a calcineurin inhibitor, FK506, and a CCR5/CXCR3 antagonist, TAK-779, in a rat small intestinal transplantation model[J]. Transplant Immunology, 2011, 25(1):0-55.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Inhibitor Library Immuno-Oncology Compound Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library Anti-Infection Compound Library Autophagy Compound Library Cytokine Inhibitor Library Nonsteroidal Anti-Inflammatory Compound Library Anti-Viral Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TAK-779 229005-80-5 Autophagy GPCR/G Protein Immunology/Inflammation Microbiology/Virology Proteases/Proteasome CXCR CCR HIV Protease HIV Human immunodeficiency virus TAK 779 Takeda779 Takeda-779 TAK779 Takeda 779 inhibit CXC chemokine receptors CC chemokine receptor Inhibitor inhibitor

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