Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 38.00 | |
5 mg | In stock | $ 89.00 | |
10 mg | In stock | $ 139.00 | |
25 mg | In stock | $ 253.00 | |
50 mg | In stock | $ 428.00 | |
100 mg | In stock | $ 639.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 97.00 |
Description | TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3). |
Targets&IC50 | MIP-1α-CCR5:1 nM (in CHO/CCR5 cells), R5 HIV-1 (Ba-L):1.2 nM (EC50, in MAGI-CCR5 cells), R5 HIV-1 (Ba-L):3.7 nM (EC50, in PBMCs), MCP-1-CCR2b:27 nM (in CHO/CCR5 cells), MIP-1β-CCR5:1 nM (in CHO/CCR5 cells), R5 HIV-1 (KK):1.6 nM (EC50, in PBMCs), RANTES-CCR5:1.4 nM (in CHO/CCR5 cells) |
In vitro | TAK-779 (250 mg/animal per day) inhibits ovalbumin-induced increases in CCR5, CXCR3, IFN-γ, and TNF-α expression in mouse lung, as well as the number of total cells, lymphocytes, and eosinophils in bronchoalveolar lavage fluid (BALF), in a mouse model of asthma[1]. |
In vivo | TAK-779 increases intestinal allograft survival in a rat model of small intestine transplantation when administered at a dose of 10 mg/kg per day[2]. |
Synonyms | Takeda 779 |
Molecular Weight | 531.13 |
Formula | C33H39ClN2O2 |
CAS No. | 229005-80-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 16.66 mg/mL (31.37 mM)
DMSO: 25 mg/mL (47.07 mM)
You can also refer to dose conversion for different animals. More
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TAK-779 229005-80-5 Autophagy GPCR/G Protein Immunology/Inflammation Microbiology/Virology Proteases/Proteasome CXCR CCR HIV Protease HIV Human immunodeficiency virus TAK 779 Takeda779 Takeda-779 TAK779 Takeda 779 inhibit CXC chemokine receptors CC chemokine receptor Inhibitor inhibitor