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TC-G 1005

Catalog No. T8818Cas No. 1415407-60-1

TC-G 1005 is a potent and selective GPBA agonist (EC50 :0.72 nM; hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and reduces blood glucose in mice. Orally available.

TC-G 1005

TC-G 1005

Purity: 99.23%
Catalog No. T8818Cas No. 1415407-60-1
TC-G 1005 is a potent and selective GPBA agonist (EC50 :0.72 nM; hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and reduces blood glucose in mice. Orally available.
Pack SizePriceAvailabilityQuantity
1 mg$30In Stock
2 mg$38In Stock
5 mg$63In Stock
10 mg$97In Stock
25 mg$198In Stock
50 mg$298In Stock
100 mg$445In Stock
1 mL x 10 mM (in DMSO)$69In Stock
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Purity:99.23%
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Product Introduction

Bioactivity
Description
TC-G 1005 is a potent and selective GPBA agonist (EC50 :0.72 nM; hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and reduces blood glucose in mice. Orally available.
Targets&IC50
TGR5 (human):0.72 nM
Chemical Properties
Molecular Weight399.48
FormulaC25H25N3O2
Cas No.1415407-60-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 10 mg/mL (25.03 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5033 mL12.5163 mL25.0325 mL125.1627 mL
5 mM0.5007 mL2.5033 mL5.0065 mL25.0325 mL
10 mM0.2503 mL1.2516 mL2.5033 mL12.5163 mL
20 mM0.1252 mL0.6258 mL1.2516 mL6.2581 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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