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Tacedinaline

Catalog No. T1888 CAS 112522-64-2

Synonyms: Acetyldinaline, N-acetyldinaline, PD-123654, CI994, Goe-5549

Tacedinaline (CI994) is a selective class I HDAC inhibitor with potential antineoplastic activity.

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Tacedinaline, CAS 112522-64-2

Pack Size	Availability	Price/USD
10 mg	In stock	$ 43.00
50 mg	In stock	$ 66.00
100 mg	In stock	$ 97.00
200 mg	In stock	$ 171.00
500 mg	In stock	$ 369.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 99.12%

Purity: 98.37%

Purity: 96.83%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Tacedinaline (CI994) is a selective class I HDAC inhibitor with potential antineoplastic activity.
Targets&IC50	HDAC1:0.9 μM, HDAC3:1.2 μM, HDAC2:0.9 μM
In vitro	In models of chemotherapy-resistant pancreatic ductal adenocarcinoma in mice and human prostate tumor, CI-994 consistently demonstrated antitumor activity.
In vivo	CI-994 exhibits antitumor activity, displaying enhanced cytocidal effects in solid tumors. It inhibits cell growth across various cell types, including rat leukemia BCLO cells (IC50=2.5 µM) and LNCaP cells (IC50=7.4 µM). In A-549 and LX-1 cells, CI-994 (<160 mM) increases the number of cells in the G0/G1 phase while decreasing those in the S phase, effectively inhibiting cell growth and inducing apoptosis.
Cell Research	LNCaP cell lines are maintained in RPMI 1640 medium containing 10% fetal bovine serum, 1% penicillin and streptomycin, as the complete culture medium. Cells (2×104) are seeded in 24-well plates and incubated in a 5% CO2 incubator at 37 °C for 1 day. Cultures are treated with CI-994, alone and in combination on day 2 and 4. Cells are washed on day 2 and 4 and media are changed. Mitochondrial metabolism is measured as a marker for cell growth by adding 100 μL/well MTT (5 mg/mL in medium) with 2 hours incubation at 37 °C on Day 6. Crystals formed are dissolved in 500 μL of DMSO. The absorbance is determined using a microplate reader at 560 nm. The absorbance data are converted into cell proliferation percentage. Each assay is performed in triplicate. (Only for Reference)

Synonyms	Acetyldinaline, N-acetyldinaline, PD-123654, CI994, Goe-5549
Molecular Weight	269.3
Formula	C15H15N3O2
CAS No.	112522-64-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 26.9 mg/mL (100 mM)

References and Literature

1. Moradei OM, et al. J Med Chem. 2007, 50(23), 5543-5546. 2. Loprevite M, et al. A Oncol Res, 2005, 15(1), 39-48. 3. Gediya LK, et al. Bioorg Med Chem, 2008, 16(6), 3352-3360. 4. LoRusso PM, et al. Invest New Drugs, 1996, 14(4), 349-356. 5. Hubeek I, et al. Oncol Rep, 2008, 19(6), 1517-1523.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Inhibitor Library Anti-Cancer Active Compound Library Autophagy Compound Library Target-Focused Phenotypic Screening Library Anti-Cancer Compound Library Anti-Lung Cancer Compound Library DNA Damage & Repair Compound Library

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Keywords

Tacedinaline 112522-64-2 Apoptosis Chromatin/Epigenetic DNA Damage/DNA Repair HDAC PD 123654 Goe5549 Acetyldinaline CI-994 CI 994 N-acetyldinaline inhibit PD-123654 Inhibitor Histone deacetylases CI994 Goe 5549 Goe-5549 PD123654 inhibitor

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