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Tamibarotene

Catalog No. T6694   CAS 94497-51-5
Synonyms: NSC 608000, Am 80, Amnolake

Tamibarotene (Amnolake) is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity.

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Tamibarotene Chemical Structure
Tamibarotene, CAS 94497-51-5
Pack Size Availability Price/USD Quantity
10 mg In stock $ 39.00
25 mg In stock $ 58.00
50 mg In stock $ 72.00
100 mg In stock $ 98.00
200 mg In stock $ 155.00
500 mg In stock $ 262.00
1 g In stock $ 389.00
1 mL * 10 mM (in DMSO) In stock $ 39.00
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Purity: 98.2%
Purity: 97.22%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Tamibarotene (Amnolake) is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity.
Cell Research The CellTiter Aqueous Non-Radioactive Cell Proliferation Assay Kit is used to assess cell growth. Briefly, 10,000 cells per well are seeded in a 96-well plate and cultured in RPMI containing 2% charcoal-stripped FBS and indicated retinoid concentrations for 72 hours. At the end of the treatment period, the MTS reagent is added, cells are incubated an additional 2-4 hours, and absorbance is measured at 490 nanometers.
Synonyms NSC 608000, Am 80, Amnolake
Molecular Weight 351.44
Formula C22H25NO3
CAS No. 94497-51-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 17.6 mg/mL (50 mM)

1.1eq. NaOH: 35.1 mg/mL (100 mM)

TargetMolReferences and Literature

1. Sanda T, et al. Leukemia, 2005, 19(6), 901-909. 2. Uruno A, et al. J Leukoc Biol, 2011, 90(2), 235-247. 3. Nakazato T, et al. Cancer Sci, 2008, 99(11), 2286-2294. 4. Kawahara K, et al. Biol Pharm Bull, 2009, 32(7), 1307-1309. 6. Wang X, et al. Retinoic acid receptor alpha drives cell cycle progression and is associated with increased sensitivity to retinoids in T-cell lymphoma. Oncotarget. 2017 Apr 18;8(16):26245-26255.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Autophagy Compound Library ReFRAME Related Library Neuronal Differentiation Compound Library Lipid Metabolism Compound Library Anti-Lung Cancer Compound Library Drug-induced Liver Injury (DILI) Compound Library

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Keywords

Tamibarotene 94497-51-5 Apoptosis Autophagy Metabolism Retinoid Receptor NSC-608000 Am-80 Retinoid X receptors NSC 608000 NSC608000 Inhibitor Am80 RAR/RXR Am 80 Amnolake Retinoic acid receptors inhibit inhibitor

 

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