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Tanzisertib
Catalog No. T14895Cas No. 899805-25-5
Alias CC-930
Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity.
Tanzisertib
Catalog No. T14895Alias CC-930Cas No. 899805-25-5
Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $35 | In Stock | |
| 5 mg | $89 | In Stock | |
| 10 mg | $148 | In Stock | |
| 25 mg | $297 | In Stock | |
| 50 mg | $588 | In Stock | |
| 100 mg | $783 | In Stock | |
| 200 mg | $1,080 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $88 | In Stock |
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Purity:99.28%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity. |
| Targets&IC50 | JNK3:6 nM, JNK1:61 nM, JNK2:7 nM |
| In vitro | Tanzisertib (CC-930) inhibits the formation of phospho-cJun in human PBMC stimulated by phorbol-12-myristate-13-acetate and phytohemeagglutinin (IC50=1 μM)[1] and blocks the JNK pathway activated by pro-fibrotic cytokines in systemic sclerosis[3]. Tanzisertib (CC-930) (1-2 μM) substantially reduces and abrogates apoptosis and necrosis in hepatocytes, including FC-loaded WT hepatocytes[2]. |
| In vivo | Tanzisertib (CC-930), when administered orally at doses of 10 and 30 mg/kg, decreases TNFa production by 23% and 77% respectively in the acute rat LPS-induced TNFa production PK-PD model[1]. Additionally, at a dose of 150 mg/kg, Tanzisertib (CC-930) not only prevents the development of fibrosis across various models but also reverses pre-existing fibrosis[3]. |
| Alias | CC-930 |
| Molecular Weight | 448.44 |
| Formula | C21H23F3N6O2 |
| Cas No. | 899805-25-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 33 mg/mL (73.59 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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