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Tavaborole

Catalog No. T3349 CAS 174671-46-6

Synonyms: Kerydin, AN-2690

Tavaborole (Kerydin) is a boron-containing small molecule antifungal agent with broad-spectrum activity against filamentous fungi, including both mold and yeast.

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Tavaborole, CAS 174671-46-6

Pack Size	Availability	Price/USD
10 mg	In stock	$ 42.00
25 mg	In stock	$ 54.00
50 mg	In stock	$ 58.00
100 mg	In stock	$ 66.00
200 mg	In stock	$ 83.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

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Purity: 99.94%

Purity: 98.25%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Tavaborole (Kerydin) is a boron-containing small molecule antifungal agent with broad-spectrum activity against filamentous fungi, including both mold and yeast.
In vitro	AN-2690 demonstrates a significant enhancement in efficacy, exhibiting an 8-fold increase in activity against both C. neoformans and A. fumigatus. It effectively inhibits cells expressing GlLeuRS-D444A, yet shows no inhibitory effect on cells expressing GlLeuRS or GlLeuRS-D444E.

Synonyms	Kerydin, AN-2690
Molecular Weight	151.93
Formula	C7H6BFO2
CAS No.	174671-46-6

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 28 mg/mL(184.3 mM)

References and Literature

1. Baker SJ, et al. Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis. J Med Chem. 2006 Jul 27;49(15):4447-50. 2. Zhou XL, et al. Post-transfer editing by a eukaryotic leucyl-tRNA synthetase resistant to the broad-spectrum drug AN2690. Biochem J. 2010 Sep 1;430(2):325-33.

Citations

1. Sun L, Sun L, Li X, et al. A Novel Tigecycline Adjuvant ML-7 Reverses the Susceptibility of Tigecycline-Resistant Klebsiella pneumoniae. Frontiers in cellular and infection microbiology. 2022: 1341.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Fluorochemical Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compound Library Anti-Fungal Compound Library Bioactive Compounds Library Max Anti-Infection Compound Library Antibiotics Library FDA-Approved Drug Library Approved Drug Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Tavaborole 174671-46-6 Microbiology/Virology Antifungal Antibiotic Kerydin Fungal AN-2690 Inhibitor inhibit AN2690 AN 2690 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.