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Timapiprant

Catalog No. T2664 CAS 851723-84-7

Synonyms: Inhibitor, OC-000459, Timapiprant, Prostaglandin Receptor, inhibit, OC 000459, OC000459

OC000459 is a potent and selective D prostanoid receptor 2 (DP2) antagonist (IC50: 13 nM).

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Timapiprant, CAS 851723-84-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	OC000459 is a potent and selective D prostanoid receptor 2 (DP2) antagonist (IC50: 13 nM).
Targets&IC50	DP2:13 nM

Synonyms	Inhibitor, OC-000459, Timapiprant, Prostaglandin Receptor, inhibit, OC 000459, OC000459
Molecular Weight	348.377
Formula	C21H17FN2O2
CAS No.	851723-84-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: <1 mg/mL

H2O: <1 mg/mL

DMSO: 4 mg/mL (11.48 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Pettipher R, et al. J Pharmacol Exp Ther, 2012, 340(2), 473-482. 2. Barnes N, et al. Clin Exp Allergy, 2012, 42(1), 38-48. 3. Singh D, et al. Eur Respir J, 2012 Apr 10.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library GPCR Compound Library Endocrinology-Hormone Compound Library Inhibitor Library Immunology/Inflammation Compound Library Fluorochemical Library Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.