Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tolrestat (AY-27773) is a potent inhibitor of aldose reductase (IC50 = 35 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 80.00 | |
2 mg | In stock | $ 118.00 | |
5 mg | In stock | $ 168.00 | |
10 mg | In stock | Inquiry | |
50 mg | In stock | Inquiry | |
1 mL * 10 mM (in DMSO) | In stock | $ 189.00 |
Description | Tolrestat (AY-27773) is a potent inhibitor of aldose reductase (IC50 = 35 nM). |
Targets&IC50 | Aldose reductase:35 nM |
In vivo | The estimated ID in the sciatic nerve and lenses is 4.8 and about 20 for tolrestat, and 1.7 and 2.2 for (±)sorbinil, respectively in diabetic rats[1]. Tolrestat inhibits tissue AR activity but does not significantly affect plasma lipoprotein levels, or affect the body weight of the mice or their general health. Accumulation of cholesterol-rich foam cells is significantly increased in aortic roots of tolrestat-fed mice[2]. Tolrestat (1.8 mg/kg) causes a reversal of normal RBC sorbitol levels[3]. |
Synonyms | AY-27773 |
Molecular Weight | 357.35 |
Formula | C16H14F3NO3S |
CAS No. | 82964-04-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (279.84 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Tolrestat 82964-04-3 Endocrinology/Hormones Metabolism Reductase Inhibitor inhibit AY27773 AY 27773 AY-27773 Aldose Reductase inhibitor