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Trimetazidine dihydrochloride

Catalog No. T0988 CAS 13171-25-0

Synonyms: Yoshimilon, Kyurinett, Vastarel F

Trimetazidine dihydrochloride (Vastarel F) can improve myocardial glucose utilization by inhibiting fatty acid metabolism. Trimetazidine is the first cytoprotective anti-ischemic agent, also used as a vasodilator in ischemic heart disease or angina.

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Trimetazidine dihydrochloride Chemical Structure

Trimetazidine dihydrochloride, CAS 13171-25-0

Pack Size	Availability	Price/USD
25 mg	In stock	$ 34.00
50 mg	In stock	$ 47.00
100 mg	In stock	$ 68.00
500 mg	In stock	$ 165.00
1 mL * 10 mM (in DMSO)	In stock	$ 30.00

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Purity: 99.31%

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Description	Trimetazidine dihydrochloride (Vastarel F) can improve myocardial glucose utilization by inhibiting fatty acid metabolism. Trimetazidine is the first cytoprotective anti-ischemic agent, also used as a vasodilator in ischemic heart disease or angina.
Targets&IC50	Long-chain 3-ketoacyl thiolase (mitochondrial):75 nM
In vitro	Trimetazidine up-regulates miR-21 expression, then miR-21 targets PTEN increasing the PI3K pathway and finally the activation of this pathway counteracts the apoptotic effect of hypoxia/reperfusion[3].
In vivo	The administration of TMZ reduces myocardial infarction size in WT C57BL/6J hearts. Both AMPK and ERK signaling pathways mediate the cardioprotection of TMZ against ischemic injury. Trimetazidine Shifts Metabolism from Fatty Acid Oxidation to Glucose Oxidation and improves Contractile Functions of Cardiomyocytes during Hypoxia[2].
Cell Research	The H9C2 cells are randomly assigned into three groups: Sham group, in which the cells are treated with 0μM TMZ for 48 h and then cultured under normal oxygenation conditions (5% CO2, and 95% air); H/R group, in which cells are treated with 0 μM TMZ for 48 h and then cultured under H/R conditions; and H/R+TMZ group, in which cells are treated with 10 μM TMZ for 48 h and then subjected to H/R treatment. (Only for Reference)

Synonyms	Yoshimilon, Kyurinett, Vastarel F
Molecular Weight	339.258
Formula	C14H24Cl2N2O3
CAS No.	13171-25-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 70 mg/mL (206.33 mM), Sonication and heating are recommended.

References and Literature

1. Kantor PF, et al. Circ Res. 2000, 86(5):580-588. 2. Liu Z, et al. Metabolism. 2016, 65(3):122-130. 3. Yang Q, et al. Int J Clin Exp Pathol. 2015, 8(4):3735-3741.

Citations

1. Chen B, Huang Y, He S, et al.N6-methyladenosine modification in 18S rRNA promotes tumorigenesis and chemoresistance via HSF4b/HSP90B1/mutant p53 axis.Cell Chemical Biology.2023, 30(2): 144-158. e10.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Inhibitor Library Anti-Cancer Approved Drug Library EMA Approved Drug Library Anti-Aging Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Approved Drug Library

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Keywords

Trimetazidine dihydrochloride 13171-25-0 Autophagy Metabolism Fatty Acid Synthase inhibit Trimetazidine Inhibitor Trimetazidine Dihydrochloride Yoshimilon Kyurinett Vastarel F inhibitor

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