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Triptolide

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Purity:99.83%

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COA HPLC

Triptolide

Catalog No. T2179Cas No. 38748-32-2

Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation. Triptolide exhibits immunosuppressive, anti-rheumatic, anti-inflammatory, anti-proliferative and anti-tumor activities.

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Pack Size	Price	Availability
1 mg	$37	In Stock
2 mg	$53	In Stock
5 mg	$97	In Stock
10 mg	$139	In Stock
25 mg	$327	In Stock
50 mg	$487	In Stock
100 mg	$583	In Stock
1 mL x 10 mM (in DMSO)	$77	In Stock

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Product Introduction

Bioactivity

Description	Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation. Triptolide exhibits immunosuppressive, anti-rheumatic, anti-inflammatory, anti-proliferative and anti-tumor activities.
In vitro	METHODS: Neuroblastoma cells BE(2)-C were treated with Triptolide (5-100 nM) for 24 h. Cell viability was measured using the CCK-8 Assay. RESULTS: A concentration-dependent response to Triptolide was observed in BE(2)-C cells. At 50 nM Triptolide, cell viability was significantly reduced to 50%. [1] METHODS: Breast cancer cells MCF-7 were treated with Triptolide (10-50 nmol/L) for 24 h, and the expression levels of target proteins were detected using Western Blot. RESULTS: Triptolide decreased the messenger RNA and protein levels of ERα in MCF-7 cells in a dose-dependent manner. [2]
In vivo	METHODS: To assay antitumor activity in vivo, Triptolide (0.4 mg/kg) was administered by gavage to BALB/c-nu+/nu+ mice harboring the breast cancer tumor MCF-7 once daily for three weeks. RESULTS: Triptolide inhibited the growth of MCF-7 cell xenografts in a mouse model. [2] METHODS: To investigate the effects on ulcerative colitis (UC), Triptolide (0.1-0.4 mg/kg) was administered orally to DSS-induced UC mice once daily for seven days. RESULTS: Triptolide has anti-inflammatory and therapeutic effects on UC mice. [3]
Cell Research	Triptolide is dissolved in DMSO (1 mg/mL) and stored, and then diluted with RPMI 1640 medium before use[3]. The viability of differentiated PC12 cells treated with different concentrations of Triptolide. After differentiated PC12 cells are cultured on 96-well plates with RPMI 1640 medium for stabilization, differentiated PC12 cells are incubated with different concentrations of Triptolide (0.01, 0.1, and 1 nM) for 24 hours. The concentrations in this study are chosen. Then cell viability is determined by the MTT assay. Each condition and experiment is repeated three times[3].
Alias	PG490, NSC 163062

Chemical Properties

Molecular Weight	360.4
Formula	C20H24O6
Cas No.	38748-32-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (138.73 mM)

5% DMSO+95% Saline: 0.36 mg/mL (1 mM, precipitation)

Solution Preparation Table

DMSO/5% DMSO+95% Saline

	1mg	5mg	10mg	50mg

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7747 mL	13.8735 mL	27.7469 mL	138.7347 mL
5 mM	0.5549 mL	2.7747 mL	5.5494 mL	27.7469 mL
10 mM	0.2775 mL	1.3873 mL	2.7747 mL	13.8735 mL
20 mM	0.1387 mL	0.6937 mL	1.3873 mL	6.9367 mL
50 mM	0.0555 mL	0.2775 mL	0.5549 mL	2.7747 mL
100 mM	0.0277 mL	0.1387 mL	0.2775 mL	1.3873 mL

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