Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GABAA receptor antagonist that binds the picrotoxin site and stabilizes the inactive form of the channel via allosteric interaction. Accelerates the decay of GABA-induced Cl- currents with little effect on peak amplitude. Also inhibits 5-HT3A receptors via a similar mechanism.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 39.00 | |
10 mg | In stock | $ 64.00 | |
25 mg | In stock | $ 128.00 | |
50 mg | In stock | $ 198.00 | |
100 mg | In stock | $ 369.00 | |
500 mg | In stock | $ 869.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 43.00 |
Description | GABAA receptor antagonist that binds the picrotoxin site and stabilizes the inactive form of the channel via allosteric interaction. Accelerates the decay of GABA-induced Cl- currents with little effect on peak amplitude. Also inhibits 5-HT3A receptors via a similar mechanism. |
Targets&IC50 | GABAA:100 nM |
In vitro | In the presence of U93631 at 5 UM, the peak amplitude decreased as a function of GABA concentration, with the half-maximal inhibitory concentration being approximately 100 nM, which is close to the Kd for the high affinity GABA site(85 nM). It appears that the drug interacts with GABA-bound receptors (at least monoliganded) and accelerates receptor desensitization, rather than acting as an open channel blocker. |
Molecular Weight | 299.37 |
Formula | C17H21N3O2 |
CAS No. | 152273-12-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (183.72 mM)
You can also refer to dose conversion for different animals. More
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U93631 152273-12-6 Membrane transporter/Ion channel Neuroscience GABA Receptor U 93631 U-93631 Inhibitor γ-Aminobutyric acid Receptor inhibit Gamma-aminobutyric acid Receptor inhibitor