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USP25/28 inhibitor AZ1
Catalog No. T7685Cas No. 2165322-94-9
Alias AZ1
USP25/28 inhibitor AZ1 is a selective, orally active and non-competitive dual ubiquitin-specific protease USP25/28 inhibitor with IC50 of 0.7 μM and 0.6 μM, respectively, and exhibits anti-inflammatory and anti-tumor effects.
USP25/28 inhibitor AZ1
Catalog No. T7685Alias AZ1Cas No. 2165322-94-9
USP25/28 inhibitor AZ1 is a selective, orally active and non-competitive dual ubiquitin-specific protease USP25/28 inhibitor with IC50 of 0.7 μM and 0.6 μM, respectively, and exhibits anti-inflammatory and anti-tumor effects.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $30 | In Stock | |
| 5 mg | $64 | In Stock | |
| 10 mg | $98 | In Stock | |
| 25 mg | $222 | In Stock | |
| 50 mg | $338 | In Stock | |
| 100 mg | $497 | In Stock | |
| 500 mg | $1,090 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $71 | In Stock |
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Purity:99.79%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | USP25/28 inhibitor AZ1 is a selective, orally active and non-competitive dual ubiquitin-specific protease USP25/28 inhibitor with IC50 of 0.7 μM and 0.6 μM, respectively, and exhibits anti-inflammatory and anti-tumor effects. |
| Targets&IC50 | USP28:0.6 nM, USP25:0.7 nM |
| In vitro | METHODS: HCT116 cells were treated with USP25/28 inhibitor AZ1 (20, 40, 60, 80, 100 μM) and samples were collected 3 hours later for Western blot analysis of USP28, c-Myc and PARP. RESULTS Western blot analysis showed that the total protein level of c-Myc decreased rapidly and concentration-dependently after treatment with USP25/28 inhibitor AZ1. [1] |
| In vivo | Method: USP25/28 inhibitor AZ1 (AZ1) (20, 40mg/kg, gavage) was given to WT Model mice were used to study the effect of USP25/28 inhibitor AZ1 (AZ1) on DSS-induced colitis. RESULTS USP25/28 inhibitor AZ1 (AZ1) treatment significantly reduced the number of colon tumors; the expression of wnt-related genes and pSTAT3 levels in tumors in the USP25/28 inhibitor AZ1 (AZ1) treatment group were reduced, and the SOCS3 level was increased; USP25/28 inhibitor Inflammation and bacterial replication were impaired in the colon of mice gavaged with AZ1 (AZ1), the expression of pro-inflammatory cytokines and antimicrobial peptides was enhanced, p-p65 and p-p38 levels were increased, and TRAF3 levels were decreased. [2] |
| Alias | AZ1 |
| Molecular Weight | 422.21 |
| Formula | C17H16BrF4NO2 |
| Cas No. | 2165322-94-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 250 mg/mL (592.12 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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