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VER-50589

Catalog No. T2258 CAS 747413-08-7

Synonyms: VER50589

VER-50589 is a potent HSP90 inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

VER-50589, CAS 747413-08-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 47.00
2 mg	In stock	$ 68.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 198.00
25 mg	In stock	$ 347.00
50 mg	In stock	$ 516.00
100 mg	In stock	$ 736.00
1 mL * 10 mM (in DMSO)	In stock	$ 98.00

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Purity: 100%

Purity: 99.95%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	VER-50589 is a potent HSP90 inhibitor.
Targets&IC50	HSP90 β:21 nM
Kinase Assay	Fluorescence Polarization Assay: Binding of HSP90 inhibitors to human full-length recombinant HSP90β is determined by a competitive binding fluorescence polarization assay, using a fluorescent pyrazole resorcinol probe.
Cell Research	Antiproliferative effects are measured using the sulforhodamine B assay. HUVEC sensitivity is determined by an alkaline phosphatase method.(Only for Reference)

Synonyms	VER50589
Molecular Weight	388.8
Formula	C19H17ClN2O5
CAS No.	747413-08-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 71 mg/mL (182.6 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 71 mg/mL (182.6 mM)

References and Literature

1. Sharp SY, et al. Mol Cancer Ther. 2007, 6(4), 1198-1211.

Citations

1. Li J, Han X, Sun M, et al.Caspase-9 inhibition triggers Hsp90-based chemotherapy-mediated tumor intrinsic innate sensing and enhances antitumor immunity.Journal for Immunotherapy of Cancer.2023, 11(12).

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Apoptosis Compound Library Target-Focused Phenotypic Screening Library Anti-Cancer Compound Library Bioactive Compound Library Metabolism Compound Library Endoplasmic Reticulum Stress Compound Library HIF-1 Signaling Pathway Compound Library Anti-Aging Compound Library Oxidation-Reduction Compound Library

Related Products

Related compounds with same targets

L-Glutamic acid DPN VPC-70063 Ro 41-5253 Oleic acid O6-Benzylguanine Sodium Oxamate Alofanib

Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

VER-50589 747413-08-7 Apoptosis Cytoskeletal Signaling Metabolism HSP VER 50589 VER50589 Inhibitor Heat shock proteins inhibit inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.