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VER-50589
Catalog No. T2258Cas No. 747413-08-7
Alias VER50589
VER-50589 is a potent HSP90 inhibitor.
VER-50589
Catalog No. T2258Alias VER50589Cas No. 747413-08-7
VER-50589 is a potent HSP90 inhibitor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $47 | In Stock | |
| 2 mg | $68 | In Stock | |
| 5 mg | $122 | In Stock | |
| 10 mg | $198 | In Stock | |
| 25 mg | $347 | In Stock | |
| 50 mg | $516 | In Stock | |
| 100 mg | $736 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $98 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | VER-50589 is a potent HSP90 inhibitor. |
| Targets&IC50 | HSP90 β:21 nM |
| In vitro | The induction of HSP72 and HSP27 by VER-50589 was accompanied by depletion of client proteins (including C-RAF, B-RAF, and survivin) and the protein arginine methyltransferase PRMT5, which further led to cell cycle arrest and apoptosis.VER-50589 inhibited the intrinsic ATPase activity of recombinant yeast Hsp90 with an IC50 of 143 nM, and inhibited the intrinsic ATPase activity of recombinant yeast Hsp90 in vitro with an IC50 of 143 nM. and produced antiproliferative activity in a panel of human cancer cell lines and non-tumorigenic cells in vitro. |
| In vivo | The induction of HSP72 and HSP27 by VER-50589 was accompanied by depletion of client proteins (including C-RAF, B-RAF, and survivin) and the protein arginine methyltransferase PRMT5, which further led to cell cycle arrest and apoptosis.VER-50589 inhibited the intrinsic ATPase activity of recombinant yeast Hsp90 with an IC50 of 143 nM, and inhibited the intrinsic ATPase activity of recombinant yeast Hsp90 in vitro with an IC50 of 143 nM. and produced antiproliferative activity in a panel of human cancer cell lines and non-tumorigenic cells in vitro. |
| Kinase Assay | Fluorescence Polarization Assay: Binding of HSP90 inhibitors to human full-length recombinant HSP90β is determined by a competitive binding fluorescence polarization assay, using a fluorescent pyrazole resorcinol probe. |
| Cell Research | Antiproliferative effects are measured using the sulforhodamine B assay. HUVEC sensitivity is determined by an alkaline phosphatase method.(Only for Reference) |
| Alias | VER50589 |
| Molecular Weight | 388.8 |
| Formula | C19H17ClN2O5 |
| Cas No. | 747413-08-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 71 mg/mL (182.6 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 71 mg/mL (182.6 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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