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WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $44 | In Stock | |
10 mg | $70 | In Stock | |
25 mg | $126 | In Stock | |
50 mg | $225 | In Stock | |
100 mg | $415 | In Stock | |
1 mL x 10 mM (in DMSO) | $64 | In Stock |
Description | WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. |
Targets&IC50 | Proliferation (β cells):28 nM(ec50) |
In vivo | In the mouse β-cell line R7T1, WS3 induces cell proliferation with an EC50 of 0.074 μM. Additionally, WS3 reversibly induces cell proliferation in primary embryonic and adult retinal pigment epithelial cells. |
Cell Research | R7T1 cells are growth-arrested by removal of doxycycline for 2 days and plated into 384-well plates at a density of 3,000 cells/well in growth medium. Β cell proliferation is assessed using CellTiter Glo after 4 days. Fold increase in cell number is calculated by normalizing compound-treated wells to the median of DMSO-treated wells. (Only for Reference) |
Molecular Weight | 569.58 |
Formula | C28H30F3N7O3 |
Cas No. | 1421227-52-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 93 mg/mL (163.3 mM) Ethanol: 74 mg/mL (129.9 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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