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WS3

Catalog No. T2055Cas No. 1421227-52-2

WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.

WS3

WS3

Purity: 98.81%
Catalog No. T2055Cas No. 1421227-52-2
WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
Pack SizePriceAvailabilityQuantity
5 mg$44In Stock
10 mg$70In Stock
25 mg$126In Stock
50 mg$225In Stock
100 mg$415In Stock
1 mL x 10 mM (in DMSO)$64In Stock
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Purity:98.81%
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Product Introduction

Bioactivity
Description
WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
Targets&IC50
Proliferation (β cells):28 nM(ec50)
In vivo
In the mouse β-cell line R7T1, WS3 induces cell proliferation with an EC50 of 0.074 μM. Additionally, WS3 reversibly induces cell proliferation in primary embryonic and adult retinal pigment epithelial cells.
Cell Research
R7T1 cells are growth-arrested by removal of doxycycline for 2 days and plated into 384-well plates at a density of 3,000 cells/well in growth medium. Β cell proliferation is assessed using CellTiter Glo after 4 days. Fold increase in cell number is calculated by normalizing compound-treated wells to the median of DMSO-treated wells. (Only for Reference)
Chemical Properties
Molecular Weight569.58
FormulaC28H30F3N7O3
Cas No.1421227-52-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 93 mg/mL (163.3 mM)
Ethanol: 74 mg/mL (129.9 mM)
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM1.7557 mL8.7784 mL17.5568 mL87.7840 mL
5 mM0.3511 mL1.7557 mL3.5114 mL17.5568 mL
10 mM0.1756 mL0.8778 mL1.7557 mL8.7784 mL
20 mM0.0878 mL0.4389 mL0.8778 mL4.3892 mL
50 mM0.0351 mL0.1756 mL0.3511 mL1.7557 mL
100 mM0.0176 mL0.0878 mL0.1756 mL0.8778 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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