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Wedelolactone

Catalog No. T3384 CAS 524-12-9

Synonyms: IKK Inhibitor II

Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.

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Wedelolactone, CAS 524-12-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 30.00
5 mg	In stock	$ 68.00
10 mg	In stock	$ 117.00
25 mg	In stock	$ 195.00
50 mg	In stock	$ 349.00
100 mg	In stock	$ 459.00
500 mg	In stock	$ 1,060.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 99.76%

Purity: 99.42%

Purity: 99%

Purity: 98.6%

Purity: 98.07%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.
Targets&IC50	5-LOX:2.5 μM (IC50)
Source	Natural Products > Asteraceae > Eclipta

Synonyms	IKK Inhibitor II
Molecular Weight	314.25
Formula	C16H10O7
CAS No.	524-12-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 57 mg/mL(181.4 mM)

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

References and Literature

1. Nehybová T, et al. Wedelolactone Acts as Proteasome Inhibitor in Breast Cancer Cells. Int J Mol Sci. 2017 Mar 29;18(4). 2. ROMANCHIKOVA N, TRAPENCIERIS P. Wedelolactone Targets EZH2-mediated Histone H3K27 Methylation in Mantle Cell Lymphoma[J]. Anticancer research. 2019, 39(8): 4179-4184.

Citations

1. Pan H, Lin Y, Dou J, et al. Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis. Cell Proliferation. 2020, 53(9): e12868 2. ROMANCHIKOVA N, TRAPENCIERIS P. Wedelolactone Targets EZH2-mediated Histone H3K27 Methylation in Mantle Cell Lymphoma. Anticancer Research. 2019, 39(8): 4179-4184 3. Wang Z, Yan H, He F, et al.Inhibition of Herpes Simplex Virus by Wedelolactone via Targeting Viral Envelope and Cellular TBK1/IRF3 and SOCS1/STAT3 pathways.International Journal of Antimicrobial Agents.2023: 107000. 4. Chen J, Zhou X, Fu L, et al.Natural Product-Based Screening for Lead Compounds Targeting SARS CoV-2 Mpro[J]. Pharmaceuticals, 2023, 16(5): 767..Pharmaceuticals.2023, 16(5): 767. 5. Chen P, Zhu Z, Geng H, et al.Integrated Spatial Metabolomics and Transcriptomics Decipher the Hepatoprotection Mechanisms of Wedelolactone and Demethylwedelolactone on Non-alcoholic Fatty Liver Disease.Journal of Pharmaceutical Analysis.2023 6. Cai R, Gong X, Li X, et al.Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma.Respiratory Research.2024, 25(1): 1-19.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library HIF-1 Signaling Pathway Compound Library Anti-Aging Compound Library Anti-Gastroenteritis Natural Product Library Antioxidant Compound Library Selected Plant-Sourced Compound Library Metabolism Compound Library Anti-Ovarian Cancer Compound Library Oxidation-Reduction Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Wedelolactone 524-12-9 Apoptosis Metabolism NF-Κb Proteases/Proteasome Caspase Lipoxygenase NF-κB LOX Eclipta alba Wedelia chinensis osteoclast Inhibitor BMSC prostate cancer inhibit IKK Inhibitor II migration inhibitor

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