Others BMI-1 XMD8-92


Catalog No. T1843   CAS 1234480-50-2
Purity 98.19% Datasheet

XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).

XMD8-92, CAS 1234480-50-2
Pack Size Availability Price/USD Quantity
5 mg In stock 60.00
10 mg In stock 95.00
25 mg In stock 220.00
50 mg In stock 367.00
100 mg In stock 590.00
1 mL * 10 mM (in DMSO) In stock 60.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).
Targets&IC50 BMI-1 :ic50 80nM(Kd),  
Kinase Assay KiNativ profiling of XMD8-92 is carried out with both an ATP and ADP acylphosphate-desthiobiotin with the following modifications. HeLa cell lysates (5 mg/mL total protein) are incubated in the presence of XMD8-92 at 50 μM, 10 μM, 2 μM, 0.8 μM, and 0 μM for 15 minutes prior to addition of the ATP or ADP acylphosphate probe (5 μM final probe concentration). All reactions are performed in duplicate. Probe reactions proceeded for 10 minutes and the reaction stopped by the addition of urea and processed for MS analysis. Samples are analyzed by LC-MS/MS on a linear ion trap mass spectrometer using a time segmented “target list” designed to collect MS/MS spectra from all kinase peptide-probe conjugates that can be detected in HeLa cell lysates. This target list is generated and validated by prior exhaustive analysis of HeLa lysates. Up to four characteristic fragment ions for each kinase peptide-probe conjugate are used to extract signals for each kinase, and a comparison of inhibitor treated to control (untreated) lysates allow for precise determination of % inhibition at each point. A manuscript describing the details of this targeted mass spectrometry approach is in preparation[1].
Animal Research
Animal Model: Mice
Molecular Weight 474.55
Formula C26H30N6O3
CAS No. 1234480-50-2


-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 19 mg/mL (40 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )


References and Literature
1. Yang Q, et al. Cancer Cell. 2010, 18(3), 258-267. 2. Dong H, et al. Pharm Biol. 2013. doi:10.3109/13880209. 3. Sureban SM, et al. Cancer Lett. 2014 , 351(1), 151-161.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library

Related Products

Related compounds with same targets
PTC596 PTC-028 XMD8-92 PTC209 PRT 4165 PTC-209 HBr

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