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ZX-29

Catalog No. T13416   CAS 2254805-62-2

ZX-29 is a potent and selective inhibitor of ALK(IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively), and also induces protective autophagy and has antitumor effect.

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ZX-29 Chemical Structure
ZX-29, CAS 2254805-62-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 97.00
5 mg In stock $ 247.00
10 mg In stock $ 397.00
25 mg In stock $ 663.00
50 mg In stock $ 945.00
100 mg In stock $ 1,280.00
1 mL * 10 mM (in DMSO) In stock $ 317.00
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Purity: 98.32%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description ZX-29 is a potent and selective inhibitor of ALK(IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively), and also induces protective autophagy and has antitumor effect.
Targets&IC50 ALK:2.1 nM , ALK L1196M:1.3 nM , ALK G1202R:3.9 nM
In vitro ZX-29 dose-dependently inhibits colony formation of NCI-H2228 cells. With an increase in ZX-29 concentration, the cell density decreased gradually, and the cells lost their normal morphology and become sharp and slender. In NCI-H2228 cells, ZX-29 (10 nM; 0-48 hours) inhibits the proliferation of and arrests the cells in G1 phase. ZX-29 (0-81 nM; 24-72 hours) treatment resulted in a decrease in the viability with time and dose. ZX-29 (10 nM; 24 hours) treatment causes typical signs of autophagy and the formation of autophagosomes and enhances the expression level of LC3 and Beclin1. ZX-29 (20 nM; 0-48 hours) treatment significantly increases the mRNA level of CHOP[1].
In vivo In a mouse xenograft model, ZX-29 treatment suppresses tumor growth[1].
Molecular Weight 518.03
Formula C23H28ClN7O3S
CAS No. 2254805-62-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 42.5 mg/mL (82.04 mM)

TargetMolReferences and Literature

1. Gou W, et al. ZX-29, a novel ALK inhibitor, induces apoptosis via ER stress in ALK rearrangement NSCLC cells and overcomes cell resistance caused by an ALK mutation. Biochim Biophys Acta Mol Cell Res. 2020 Mar 26;1867(7):118712.

Related compound libraries

This product is contained In the following compound libraries:
Tyrosine Kinase Inhibitor Library Anti-Cancer Active Compound Library Kinase Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Cancer Compound Library Inhibitor Library Anti-Lung Cancer Compound Library Angiogenesis related Compound Library

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Keywords

ZX-29 2254805-62-2 Angiogenesis Tyrosine Kinase/Adaptors ALK arrest antitumor ZX29 Resistance Anaplastic lymphoma kinase Bcl-2 Apoptosis Inhibitor CD246 p-Akt caspase-3 endoplasmic inhibit CHOP Anaplastic lymphoma kinase (ALK) ALK tyrosine kinase receptor ERS Cluster of differentiation 246 Autophagy reticulum p-STAT3 ZX 29 inhibitor

 

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