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Zileuton

Catalog No. T0477   CAS 111406-87-2
Synonyms: Abbott 64077, A 64077

Zileuton (A 64077) is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; causes bronchodilation; decreases bronchial mucous secretion and edema; and may prevent or decrease the symptoms of asthma.

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Zileuton Chemical Structure
Zileuton, CAS 111406-87-2
Pack Size Availability Price/USD Quantity
10 mg In stock $ 47.00
25 mg In stock $ 71.00
50 mg In stock $ 97.00
100 mg In stock $ 185.00
200 mg In stock $ 278.00
500 mg In stock $ 469.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.56%
Purity: 99.43%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Zileuton (A 64077) is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; causes bronchodilation; decreases bronchial mucous secretion and edema; and may prevent or decrease the symptoms of asthma.
Synonyms Abbott 64077, A 64077
Molecular Weight 236.29
Formula C11H12N2O2S
CAS No. 111406-87-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 23.6 mg/mL (100 mM)

TargetMolReferences and Literature

1. Rossi A1, et al. Br J Pharmacol, 2010, 161(3), 555-570. 2. Bertrán X, et al.Gut. 1996 Jun;38(6):899-904. 3. Genovese T, et al. Br J Pharmacol, 2008, 153(3), 568-582. 4. Patel NS, et al. Mol Pharmacol, 2004, 66(2), 220-227. 5. Rao NL, et al. J Pharmacol Exp Ther, 2007, 321(3), 1154-1160. 6. Gounaris E, et al. Zileuton, 5-lipoxygenase inhibitor, acts as a chemopreventive agent in intestinal polyposis, by modulating polyp and systemic inflammation. PLoS One. 2015 Mar 6;10(3):e0121402 7. Abueid L, et al. Inhibition of 5-lipoxygenase by zileuton in a rat model of myocardial infarction. Anatol J Cardiol. 2016 Nov 10 8. Liu L, Zhang P, Zhang Z, et al. 5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats[J]. Aging (Albany NY). 2021, 13(8): 11752.

TargetMolCitations

1. Liu L, Zhang P, Zhang Z, et al. 5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats. Aging (Albany NY). 2021, 13(8): 11752.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library NO PAINS Compound Library Anti-Metabolism Disease Compound Library Bioactive Lipid Compound Library Neuronal Signaling Compound Library Cell Cycle Compound Library Immunology/Inflammation Compound Library FDA-Approved & Pharmacopeia Drug Library

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TBHQ ML385 PRLX-93936 HCL D-glutamine Matrine NADPH tetracyclohexanamine Butylhydroxyanisole Butylated hydroxytoluene

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Zileuton 111406-87-2 Apoptosis Immunology/Inflammation Metabolism Neuroscience Ferroptosis Lipoxygenase COX A64077 Inhibitor Abbott 64077 A-64077 inhibit Abbott-64077 Abbott64077 LOX A 64077 inhibitor

 

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