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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $34 | In Stock | |
2 mg | $47 | In Stock | |
5 mg | $77 | In Stock | |
10 mg | $127 | In Stock | |
25 mg | $245 | In Stock | |
50 mg | $432 | In Stock | |
100 mg | $639 | In Stock | |
500 mg | $1,330 | In Stock | |
1 mL x 10 mM (in DMSO) | $85 | In Stock |
Description | A66 is a specific and effective p110α inhibitor(IC50=32 nM). |
Targets&IC50 | p110α:32 nM |
In vitro | In male CD1 mice, A66 (10 mg/kg) increased glucose production during the pyruvate tolerance test. In SK-OV-3 tumor tissues, A66 (100 mg/kg) effectively reduced the phosphorylation of Akt/PKB and p70 S6 kinase, inhibiting tumor cell growth. |
In vivo | A66 significantly inhibits the oncogenic forms of p110α, such as p110αE545K (IC50=30 nM) and p110αH1047R (IC50=43 nM), effectively reducing their activity. |
Kinase Assay | IC50 values are evaluated using the PI3K (human) HTRF Assay. p85α/p110δ is obtained from Invitrogen. All other isoforms are produced in-house by co-expressing full-length human p85α with the indicated human full-length catalytic subunit containing a histidine tag at the N-terminus to allow purification. The PI3Ks are titrated and used at a concentration between their EC65-EC80 values. PI3K activity in immunoprecipitates is assayed using an antibody to the N-SH2 (N-Src homology 2) domain of p85α. Assays for other lipid kinases and protein kinases are performed by the National Centre for Protein Kinase Profiling and Invitrogen Drug Discovery Services[1]. |
Molecular Weight | 393.53 |
Formula | C17H23N5O2S2 |
Cas No. | 1166227-08-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: 1 mg/mL (2.54 mM) DMSO: 60 mg/mL (152.47 mM), Sonication is recommended. ![]() | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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