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AB-423

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Purity:99.94%

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COA HPLC HNMR

AB-423

Catalog No. TQ0017Cas No. 1572510-80-5

AB-423 is an inhibitor of HBV capsid assembly and effectively inhibits HBV replication (EC50/EC90: 0.08-0.27 μM/0.33-1.32 μM in cells).

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Pack Size	Price	Availability
1 mg	$48	In Stock
5 mg	$98	In Stock
10 mg	$163	In Stock
25 mg	$328	In Stock
50 mg	$473	In Stock
100 mg	$648	In Stock
1 mL x 10 mM (in DMSO)	$113	In Stock

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Product Introduction

Bioactivity

Description	AB-423 is an inhibitor of HBV capsid assembly and effectively inhibits HBV replication (EC50/EC90: 0.08-0.27 μM/0.33-1.32 μM in cells).
In vitro	AB-423 shows an inhibitory effect on relaxed circular DNA production in AML12-HBV10 and HepDE19 cells (EC50s: ～0.260 μM). AB-423 also suppresses cccDNA formation-dependent HBeAg production in the HepBHAe82 assay (EC50: 0.267 μM) and inhibits HBV DNA levels in culture supernatants of HepG 2.2.15 cells (EC50: 0.134 μM).

Chemical Properties

Molecular Weight	386.39
Formula	C17H17F3N2O3S
Cas No.	1572510-80-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 60 mg/mL (155.28 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5881 mL	12.9403 mL	25.8806 mL	129.4029 mL
5 mM	0.5176 mL	2.5881 mL	5.1761 mL	25.8806 mL
10 mM	0.2588 mL	1.2940 mL	2.5881 mL	12.9403 mL
20 mM	0.1294 mL	0.6470 mL	1.2940 mL	6.4701 mL
50 mM	0.0518 mL	0.2588 mL	0.5176 mL	2.5881 mL
100 mM	0.0259 mL	0.1294 mL	0.2588 mL	1.2940 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc