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Paritaprevir

Name: Paritaprevir
Brand: TargetMol
SKU: T22394
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T22394Cas No. 1216941-48-8

Alias Veruprevir, ABT-450, ABT450

Paritaprevir (ABT450) is an inhibitor of non-structural protein 3/4A protease with EC50 values of 1 and 0.21 nM for HCV 1a and HCV 1b, respectively.

Paritaprevir

Purity: 98.04%

Catalog No. T22394Alias Veruprevir, ABT-450, ABT450Cas No. 1216941-48-8

Paritaprevir (ABT450) is an inhibitor of non-structural protein 3/4A protease with EC50 values of 1 and 0.21 nM for HCV 1a and HCV 1b, respectively.

Pack Size	Price	Availability
5 mg	$43	In Stock
10 mg	$58	In Stock
25 mg	$90	In Stock

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FDA-Approved Drug Library

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Inhibitor Library

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Purity:98.04%

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COA LCMS HNMR

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Product Introduction

Bioactivity

Description	Paritaprevir (ABT450) is an inhibitor of non-structural protein 3/4A protease with EC50 values of 1 and 0.21 nM for HCV 1a and HCV 1b, respectively.
Targets&IC50	HCV NS3/4A 4a:0.09 nM, HCV NS3/4A 2a:5.3 nM, HCV NS3/4A 6a:0.69nM, HCV NS3/4A 1a:1.0 nM, HCV 1b:0.21 nM(EC50), HCV NS3/4A 1b:0.21 nM, HCV NS3/4A 3a:19 nM, HCV 1a:1 nM(EC50)
In vivo	Paritaprevir/ritonavir/ombitasvir with dasabuvir (PrOD) is a novel combination of a nonstructural (NS) 3/4A protein inhibitor boosted by ritonavir, an NS5A protein inhibitor, and an NS5B nonnucleoside polymerase inhibitor. The combination of paritaprevir, ritonavir, ombitasvir (an NS5A protein inhibitor), and dasabuvir (an NS5B non-nucleoside polymerase inhibitor) with or without RBV has been approved to treat HCV genotype 1 infections1[1].
Alias	Veruprevir, ABT-450, ABT450

Chemical Properties

Molecular Weight	765.88
Formula	C₄₀H₄₃N₇O₇S
Cas No.	1216941-48-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (104.46 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3057 mL	6.5284 mL	13.0569 mL	65.2844 mL
5 mM	0.2611 mL	1.3057 mL	2.6114 mL	13.0569 mL
10 mM	0.1306 mL	0.6528 mL	1.3057 mL	6.5284 mL
20 mM	0.0653 mL	0.3264 mL	0.6528 mL	3.2642 mL
50 mM	0.0261 mL	0.1306 mL	0.2611 mL	1.3057 mL
100 mM	0.0131 mL	0.0653 mL	0.1306 mL	0.6528 mL

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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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