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Amlodipine maleate

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Purity:99.4%

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COA HPLC HNMR

Amlodipine maleate

Catalog No. T21263Cas No. 88150-47-4

Amlodipine maleate (Amvaz) is an orally active dihydropyridine calcium channel blocker that inhibits calcium inward flow by blocking voltage-dependent L-type calcium channels.Amlodipine maleate is used in the study of hypertension and cancer.

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Pack Size	Price	Availability
500 mg	$42	In Stock
1 g	$68	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock

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Product Introduction

Bioactivity

Description	Amlodipine maleate (Amvaz) is an orally active dihydropyridine calcium channel blocker that inhibits calcium inward flow by blocking voltage-dependent L-type calcium channels.Amlodipine maleate is used in the study of hypertension and cancer.
In vitro	Amlodipine maleate (30 μM; pretreated for 1 h) significantly attenuates the uridine 5′-triphosphate (UTP)-induced increases of [Ca2+]i in A431 cells.[4] Amlodipine maleate (20-40 μM; 48 h) reduces BrdU incorporation to 68.6% and 26.3% in A431 cells, respectively.[4] Amlodipine maleate (30 μM) inhibits the store-operated Ca2+influx evoked by Thapsigargin in Fluo-3-loaded cells.[4]
In vivo	Amlodipine maleate (10 mg/kg; i.p. once daily for 20 days) causes a significant retardation of tumor growth and prolongs the survival of A431 tumor-bearing mice.[4] Amlodipine maleate (5 mg/kg/day; s.c. for 2 weeks) significantly decreases systolic blood pressure (SBP) in VSMC ATP2B1 KO mice.[5]
Alias	Amlodipine (+-)-form maleate, Amvaz

Chemical Properties

Molecular Weight	524.95
Formula	C24H29ClN2O9
Cas No.	88150-47-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 108.0 mg/mL (205.7 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9049 mL	9.5247 mL	19.0494 mL	95.2472 mL
5 mM	0.3810 mL	1.9049 mL	3.8099 mL	19.0494 mL
10 mM	0.1905 mL	0.9525 mL	1.9049 mL	9.5247 mL
20 mM	0.0952 mL	0.4762 mL	0.9525 mL	4.7624 mL
50 mM	0.0381 mL	0.1905 mL	0.3810 mL	1.9049 mL
100 mM	0.0190 mL	0.0952 mL	0.1905 mL	0.9525 mL

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