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Apraclonidine hydrochloride

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Purity:98.01%

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COA HPLC HNMR

Apraclonidine hydrochloride

Catalog No. T21371Cas No. 73218-79-8

Apraclonidine hydrochloride (ALO 2145) is an α2-adrenergic agonist and a weak α-1 adrenergic receptor agonist. Apraclonidine hydrochloride lowers intraocular pressure in human eyes and can be used in studies about glaucoma therapy.

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Pack Size	Price	Availability
2 mg	$30	In Stock
5 mg	$43	In Stock
10 mg	$73	In Stock
25 mg	$133	In Stock
50 mg	$196	In Stock
100 mg	$295	In Stock
500 mg	$642	In Stock
1 mL x 10 mM (in DMSO)	$47	In Stock

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Product Introduction

Bioactivity

Description	Apraclonidine hydrochloride (ALO 2145) is an α2-adrenergic agonist and a weak α-1 adrenergic receptor agonist. Apraclonidine hydrochloride lowers intraocular pressure in human eyes and can be used in studies about glaucoma therapy.
In vitro	Apraclonidine hydrochloride penetrates the cornea and blood-brain barrier to a lesser extent[2].
In vivo	Apraclonidine hydrochloride elevats intraocular pressure as well as glaucoma. Apraclonidine reduces aqueous humor synthesis and vasoconstrictor actions at the anterior segment branches of the ophthalmic artery[2]. Apraclonidine (1.15%) causes a 98% inhibition of PGE2-induced aqueous flare elevationy[3].
Alias	Iopidine, ALO 2145, Apraclonidina, P-aminoclonidine, 4-Aminoclonidine, Apraclonidine HCl, Apraclonidinum

Chemical Properties

Molecular Weight	281.57
Formula	C9H11Cl3N4
Cas No.	73218-79-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 112.5 mg/mL (399.5 mM)

H2O: 11.2 mg/mL (40.0 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.5515 mL	17.7576 mL	35.5151 mL	177.5757 mL
5 mM	0.7103 mL	3.5515 mL	7.1030 mL	35.5151 mL
10 mM	0.3552 mL	1.7758 mL	3.5515 mL	17.7576 mL
20 mM	0.1776 mL	0.8879 mL	1.7758 mL	8.8788 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0710 mL	0.3552 mL	0.7103 mL	3.5515 mL
100 mM	0.0355 mL	0.1776 mL	0.3552 mL	1.7758 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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