Shopping Cart
- Remove All
Your shopping cart is currently empty
AZD-5672
🥰Excellent
Catalog No. T30260Cas No. 780750-65-4
Alias UNII-61XQN688TW, AZD5672, AZD 5672
AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7.3 μM and 32 μM. AZD-5672 can be used in studies about rheumatoid arthritis.
AZD-5672
🥰Excellent
Purity: 95.58%
Catalog No. T30260Alias UNII-61XQN688TW, AZD5672, AZD 5672Cas No. 780750-65-4
AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7.3 μM and 32 μM. AZD-5672 can be used in studies about rheumatoid arthritis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $213 | In Stock | |
| 5 mg | $483 | In Stock | |
| 10 mg | $677 | In Stock | |
| 25 mg | $987 | In Stock | |
| 50 mg | $1,380 | In Stock | |
| 100 mg | $1,880 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $589 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "AZD-5672"
Tannic acid
Cited
Gallotannic acid
T08011401-55-4
Tannic acid (Gallotannic acid) is a novel hERG channel blocker.
- $41
Size
QTY
CitedCinchonine Cited
LA40221, (8R,9S)-Cinchonine
T0012118-10-5
Cinchonine (LA40221), a local anesthetic of the amide type, now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local narcotics and its parenteral use is restricted to spinal anesthesia.
- $44
Size
QTY
CitedPirfenidone
Cited
S-7701,AMR-69, S-7701, AMR69
T238653179-13-8
Pirfenidone (AMR69) inhibits the production of CCL2 and CCL12 in fibroblasts and also decreases TGF-β2 protein levels. Pirfenidone is an antifibrotic agent that is commonly used in studies related to pulmonary fibrosis and also has anti-inflammatory activity.
- $30
Size
QTY
CitedNeratinib Cited
HKI-272
T2325698387-09-6
Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.
- $30
Size
QTY
CitedPolyoxyethylene stearate
POES
T165619004-99-3
Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.
- $45
Size
QTY
Afatinib Dimaleate Cited
BIBW2992, BIBW 2992MA2, Afatinib (BIBW2992) Dimaleate, Afatinib
T1773850140-73-7
Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with antineoplastic activity.
- $34
Size
QTY
CitedGlibenclamide Cited
Glyburide
T163410238-21-8
Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
- $45
Size
QTY
CitedEncequidar mesylate
HM30181A mesylate, HM30181 mesylate
T11578L849675-87-2
Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.
- $35
Size
QTY
Atazanavir sulfate
BMS-232632 sulfate
T0100229975-97-7
Atazanavir sulfate (BMS-232632 sulfate) is an azapeptide and HIV-protease inhibitor used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents.
- $39
Size
QTY
Atazanavir Cited
Zrivada, Reyataz, Latazanavir, BMS-232632
T0100L198904-31-3
Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.
- $39
Size
QTY
CitedElacridar
GW120918, GW0918, GG918, GF120918
T2657143664-11-3
Elacridar (GG918) is a potent inhibitor of P-glycoprotein and BCRP.
- $35
Size
QTY
Tucatinib Cited
ONT-380, Irbinitinib, ARRY-380
T2364937263-43-9
Tucatinib (ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM).
- $30
Size
QTY
CitedSelect Batch
Purity:95.58%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7.3 μM and 32 μM. AZD-5672 can be used in studies about rheumatoid arthritis. |
| Targets&IC50 | P-gp (human):32 μM (IC50), ERG (human):7.3 μM (IC50), CCR5:0.32 nM (IC50) |
| In vitro | In Caco-2 cells, AZD-5672 (0-100 μM) inhibits P-gp-mediated digoxin transport in a concentration-dependent manner[1]. |
| In vivo | AZD-5672 (1-2 mg/kg; i.v) shows moderate bioavailability with CI, Vss and t1/2 of 28 mL/min/kg, 5.3 L/kg, and 2.6 h in rats while 18 mL/min/kg, 5.7 L/kg, and 3.9 h in dogs[3]. |
| Alias | UNII-61XQN688TW, AZD5672, AZD 5672 |
| Molecular Weight | 632.78 |
| Formula | C32H38F2N2O5S2 |
| Cas No. | 780750-65-4 |
| Smiles | CCN(C1CCN(CC[C@H](c2ccc(cc2)S(C)(=O)=O)c2cc(F)cc(F)c2)CC1)C(=O)Cc1ccc(cc1)S(C)(=O)=O |
| Relative Density. | 1.33 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (47.4 mM), Sonication and heating to 60℃ are recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy AZD-5672 | purchase AZD-5672 | AZD-5672 cost | order AZD-5672 | AZD-5672 chemical structure | AZD-5672 in vivo | AZD-5672 in vitro | AZD-5672 formula | AZD-5672 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.