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BAY-985

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Purity:99.3%

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COA HPLC HNMR

BAY-985

Catalog No. T10477Cas No. 2409479-29-2

BAY-985 is a potent, selective, and orally active ATP-competitive dual inhibitor of TBK1 and IKKε (IC50s: 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε) with antitumor efficacy.

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Pack Size	Price	Availability
1 mg	$175	In Stock
5 mg	$372	In Stock
10 mg	$597	In Stock
25 mg	$953	In Stock
50 mg	$1,290	In Stock
100 mg	$1,730	In Stock
1 mL x 10 mM (in DMSO)	$453	In Stock

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Product Introduction

Bioactivity

Description	BAY-985 is a potent, selective, and orally active ATP-competitive dual inhibitor of TBK1 and IKKε (IC50s: 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε) with antitumor efficacy.
In vitro	BAY-985 inhibits FLT3, RSK4, DRAK1, and ULK1 (IC50s: 123, 276, 311, and 7930 nM). BAY-985 inhibits the cellular phosphorylation of interferon regulatory factor 3 (IRF3, IC50: 74 nM). BAY-985 shows anti-proliferative activity in a few cancer cell lines (IC50s: 900 and 7260 nM for SK-MEL2 (NRAS and TP53 mutated) and ACHN (CDKN2A mutated) cells).
In vivo	BAY-985 (200 mg/kg; p.o.; b.i.d.; 111 days) results in weak antitumor efficacy. BAY-985 shows high clearance (CLb= 4.0 L/h/kg, ca. 95% hepatic extraction), large volume of distribution at steady state (Vss=2.9 L/kg) and a short terminal half-life (t1/2=0.79 h).

Chemical Properties

Molecular Weight	553.58
Formula	C27H30F3N9O
Cas No.	2409479-29-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (90.32 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8064 mL	9.0321 mL	18.0642 mL	90.3212 mL
5 mM	0.3613 mL	1.8064 mL	3.6128 mL	18.0642 mL
10 mM	0.1806 mL	0.9032 mL	1.8064 mL	9.0321 mL
20 mM	0.0903 mL	0.4516 mL	0.9032 mL	4.5161 mL
50 mM	0.0361 mL	0.1806 mL	0.3613 mL	1.8064 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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