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Bezafibrate

Bezafibrate
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Purity:99.82%
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Bezafibrate

Catalog No. T0841Cas No. 41859-67-0
Bezafibrate (BM15075) is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES. It decreases LOW-DENSITY LIPOPROTEINS and increases HIGH-DENSITY LIPOPROTEINS.
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Pack SizePriceAvailabilityQuantity
50 mg$36In Stock
100 mg$50In Stock
200 mg$63In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Product Introduction

Bioactivity
Description
Bezafibrate (BM15075) is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES. It decreases LOW-DENSITY LIPOPROTEINS and increases HIGH-DENSITY LIPOPROTEINS.
In vitro
Bezafibrate significantly decreases plasma triglyceride and leptin levels without altering the expression of PPARγ in white adipose tissue or the ob gene. Treatment with Bezafibrate resulted in much smaller gonadal fat stores in wild-type and PPARβ-null mice (2.8 and ~2.6 times less, respectively) than in controls, while PPARα-null mice did not exhibit this effect. Bezafibrate altered the expression of mRNAs coding for lipid metabolism enzymes, such as AOX, CYP4A, LPL, ACS, and LCAD, in wild-type, PPARβ-null, and PPARα-null mice. It induced the expression of UCPs in rat epididymal white adipose tissue and altered energy balance by directly inducing aco gene expression (14.5-fold increase on day 7) and peroxisomal fatty acid beta-oxidation. Bezafibrate treatment upregulated mRNA levels of M-CPT-I (4.5-fold), fatty acid translocase (2.6-fold), and Pref-1 (5.6-fold) in rat epididymal white adipose tissue. Compared to controls, Bezafibrate significantly increased liver weight in wild-type and PPARβ-null mice, with no change observed in PPARα-null mice.
In vivo
Bezafibrate exhibits an EC50 of 5 μM when binding to xPPARβ. Additionally, Bezafibrate activates the transcription of Xenopus PPARβ with an EC50 of 1 μM.
AliasBM15075
Chemical Properties
Molecular Weight361.82
FormulaC19H20ClNO4
Cas No.41859-67-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 15 mg/mL (41.5 mM)
DMSO: 67 mg/mL (185.2 mM)
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM2.7638 mL13.8190 mL27.6381 mL138.1903 mL
5 mM0.5528 mL2.7638 mL5.5276 mL27.6381 mL
10 mM0.2764 mL1.3819 mL2.7638 mL13.8190 mL
20 mM0.1382 mL0.6910 mL1.3819 mL6.9095 mL
DMSO
1mg5mg10mg50mg
50 mM0.0553 mL0.2764 mL0.5528 mL2.7638 mL
100 mM0.0276 mL0.1382 mL0.2764 mL1.3819 mL

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