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Brepocitinib P-Tosylate
Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively).
Catalog No. T12427Cas No. 2140301-96-6
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Purity:99.89%
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Brepocitinib P-Tosylate
Catalog No. T12427Alias PF-06700841 P-TosylateCas No. 2140301-96-6
Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $38 | In Stock | |
| 10 mg | $64 | In Stock | |
| 25 mg | $137 | In Stock | |
| 50 mg | $248 | In Stock | |
| 100 mg | $397 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $47 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively). |
| Targets&IC50 | JAK3:6.9 μM (IC50), JAK1:17 nM (IC50), JAK2:77 nM (IC50) |
| In vitro | PF-06700841 has good potency against IL6/pStat1 in the CD3+ cellular subset (IC50 of 81 nM), but lower inhibition of IL6/pSTAT3, again in the CD3+ cellular subset (IC50 of 641 nM). |
| In vivo | PF-06700841 (oral administration; for 7 consecutive days; female Lewis rats) treatment significantly reduces paw volume increase in a dose-dependent manner[1]. |
| Alias | PF-06700841 P-Tosylate |
| Molecular Weight | 561.6 |
| Formula | C25H29F2N7O4S |
| Cas No. | 2140301-96-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 23.33 mg/mL (41.55 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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