Shopping Cart
- Remove All
- Your shopping cart is currently empty
Brimonidine Tartrate (AGN190342 tartrate) is a quinoxaline derivative and adrenergic α-2 receptor agonist (EC50: 0.45 nM) that is used to manage intraocular pressure associated with open-angle glaucoma or ocular hypertension.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 mg | $41 | In Stock | |
500 mg | $126 | In Stock |
Description | Brimonidine Tartrate (AGN190342 tartrate) is a quinoxaline derivative and adrenergic α-2 receptor agonist (EC50: 0.45 nM) that is used to manage intraocular pressure associated with open-angle glaucoma or ocular hypertension. |
Targets&IC50 | α2A-adrenoceptor:0.45 nM(EC50) |
In vitro | Brimonidine (0.5/1 mg/kg) reduced progressive ganglion cell loss (26%/15%). At elevated intraocular pressure, the use of Brimonidine significantly protected retinal ganglion cells and prevented further cell loss. Brimonidine injection into the eyes of SD rats increased the number of brain-derived neurotrophic factor-positive retinal ganglion cells from 55% to 166%. Brimonidine prevented further ganglion cell loss after 10 days of elevated IOP.Brimonidine increased immunoreactivity for glial fibrillary acidic protein in the hypertensive retina of attenuated eyes. |
In vivo | Brimonidine (0.5/1 mg/kg) reduced progressive ganglion cell loss (26%/15%). At elevated intraocular pressure, the use of Brimonidine significantly protected retinal ganglion cells and prevented further cell loss. Brimonidine injection into the eyes of SD rats increased the number of brain-derived neurotrophic factor-positive retinal ganglion cells from 55% to 166%. Brimonidine prevented further ganglion cell loss after 10 days of elevated IOP.Brimonidine increased immunoreactivity for glial fibrillary acidic protein in the hypertensive retina of attenuated eyes. |
Alias | UK14304 tartrate, UK 14304 (tartrate), AGN190342 tartrate, AGN190342 (tartrate) |
Molecular Weight | 442.22 |
Formula | C15H16BrN5O6 |
Cas No. | 70359-46-5 |
Smiles | O[C@H]([C@@H](O)C(O)=O)C(O)=O.Brc1c(NC2=NCCN2)ccc2nccnc12 |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 16.67 mg/mL (37.69 mM), Sonication is recommended. ![]() H2O: 56.53 mM, Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
|
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.