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Brimonidine Tartrate

🥰Excellent
Catalog No. T6422Cas No. 70359-46-5
Alias UK14304 tartrate, UK 14304 (tartrate), AGN190342 tartrate, AGN190342 (tartrate)

Brimonidine Tartrate (AGN190342 tartrate) is a quinoxaline derivative and adrenergic α-2 receptor agonist (EC50: 0.45 nM) that is used to manage intraocular pressure associated with open-angle glaucoma or ocular hypertension.

Brimonidine Tartrate

Brimonidine Tartrate

🥰Excellent
Purity: 99.95%
Catalog No. T6422Alias UK14304 tartrate, UK 14304 (tartrate), AGN190342 tartrate, AGN190342 (tartrate)Cas No. 70359-46-5
Brimonidine Tartrate (AGN190342 tartrate) is a quinoxaline derivative and adrenergic α-2 receptor agonist (EC50: 0.45 nM) that is used to manage intraocular pressure associated with open-angle glaucoma or ocular hypertension.
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100 mg$41 In Stock
500 mg$126 In Stock
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Purity:99.95%
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Product Introduction

Bioactivity
Description
Brimonidine Tartrate (AGN190342 tartrate) is a quinoxaline derivative and adrenergic α-2 receptor agonist (EC50: 0.45 nM) that is used to manage intraocular pressure associated with open-angle glaucoma or ocular hypertension.
Targets&IC50
α2A-adrenoceptor:0.45 nM(EC50)
In vitro
Brimonidine (0.5/1 mg/kg) reduced progressive ganglion cell loss (26%/15%). At elevated intraocular pressure, the use of Brimonidine significantly protected retinal ganglion cells and prevented further cell loss. Brimonidine injection into the eyes of SD rats increased the number of brain-derived neurotrophic factor-positive retinal ganglion cells from 55% to 166%. Brimonidine prevented further ganglion cell loss after 10 days of elevated IOP.Brimonidine increased immunoreactivity for glial fibrillary acidic protein in the hypertensive retina of attenuated eyes.
In vivo
Brimonidine (0.5/1 mg/kg) reduced progressive ganglion cell loss (26%/15%). At elevated intraocular pressure, the use of Brimonidine significantly protected retinal ganglion cells and prevented further cell loss. Brimonidine injection into the eyes of SD rats increased the number of brain-derived neurotrophic factor-positive retinal ganglion cells from 55% to 166%. Brimonidine prevented further ganglion cell loss after 10 days of elevated IOP.Brimonidine increased immunoreactivity for glial fibrillary acidic protein in the hypertensive retina of attenuated eyes.
AliasUK14304 tartrate, UK 14304 (tartrate), AGN190342 tartrate, AGN190342 (tartrate)
Chemical Properties
Molecular Weight442.22
FormulaC15H16BrN5O6
Cas No.70359-46-5
SmilesO[C@H]([C@@H](O)C(O)=O)C(O)=O.Brc1c(NC2=NCCN2)ccc2nccnc12
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 16.67 mg/mL (37.69 mM), Sonication is recommended.
H2O: 56.53 mM, Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM2.2613 mL11.3066 mL22.6132 mL113.0659 mL
5 mM0.4523 mL2.2613 mL4.5226 mL22.6132 mL
10 mM0.2261 mL1.1307 mL2.2613 mL11.3066 mL
20 mM0.1131 mL0.5653 mL1.1307 mL5.6533 mL
H2O
1mg5mg10mg50mg
50 mM0.0452 mL0.2261 mL0.4523 mL2.2613 mL

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