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CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $38 | In Stock | |
5 mg | $60 | In Stock | |
10 mg | $98 | In Stock | |
25 mg | $188 | In Stock | |
50 mg | $317 | In Stock | |
100 mg | $497 | In Stock | |
1 mL x 10 mM (in DMSO) | $67 | In Stock |
Description | CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM). |
Targets&IC50 | DNA-PK:13 nM, mTOR:21nM |
In vitro | The IC50 values for CC-115 are >10 μM against a panel of CYP enzymes and >33 μM for the hERG ion channel. When screened in a single point assay at 10 μM against a Cerep receptor and enzyme panel only one target was inhibited >50% (PDE3, IC50 = 0.63 μM). |
In vivo | CC-115 shows good PK profiles across multiple species with 53%, 76%, and 100% oral bioavailability in mouse, rat, and dog, respectively. CC-115, with favorable physicochemical and pharmacokinetic properties, demonstrates mTOR pathway inhibition and tumor growth inhibition, as well as a good safety profile, suitable for Clinicalal development. |
Cell Research | Freshly isolated CLL cells are treated with different concentrations of CC-115 for 30 minutes. Subsequently, the cells are exposed to 5-Gy γ-radiation or treated with 10 µg/mL bleomycin (EMD Millipore, Billerica, MA) and incubated for 30 minutes, and cell lysates are made. (Only for Reference) |
Alias | CC 115 |
Molecular Weight | 336.35 |
Formula | C16H16N8O |
Cas No. | 1228013-15-7 |
Smiles | CCN1C(=O)CNc2ncc(nc12)-c1ccc(nc1C)-c1ncn[nH]1 |
Relative Density. | 1.56 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 62 mg/mL (184.3 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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