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CID 2011756 is an ATP-competitive and specific PKD1 inhibitor.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $40 | In Stock | |
10 mg | $60 | In Stock | |
25 mg | $106 | In Stock | |
50 mg | $163 | In Stock | |
100 mg | $247 | In Stock | |
200 mg | $367 | In Stock | |
1 mL x 10 mM (in DMSO) | $44 | In Stock |
Description | CID 2011756 is an ATP-competitive and specific PKD1 inhibitor. |
Targets&IC50 | PKD1:3.2 μM, PKD2:0.6 μM, PKD3:0.7 μM |
Kinase Assay | Ub-PLA2 assay: Recombinant enzymes in 20 mM Tris-HCl, pH 8.0, 2 mM CaCl2 and 2 mM β-mercaptoethanol (DUB assay buffer) are preincubated with single doses or dose ranges of PR-619 or P22077 for 30 minutes in a 96 well plate before the addition of Ub-PLA2 and NBD C6-HPC. The liberation of a fluorescent product within the linear range of the assay is monitored at room temperature using a fluorescence plate reader. Vehicle (2%(v/v) DMSO) and 10 mM N-ethylmaleimide are included as controls. Where ≥60% inhibition is observed, EC50 values are determined using a sigmoidal dose response equation. |
Alias | CID-2011756, CID2011756 |
Molecular Weight | 396.87 |
Formula | C22H21ClN2O3 |
Cas No. | 638156-11-3 |
Smiles | Clc1cccc(c1)-c1ccc(o1)C(=O)Nc1ccc(CN2CCOCC2)cc1 |
Relative Density. | 1.297 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 15 mg/mL (37.8 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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