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CID 2011756

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Catalog No. T1863Cas No. 638156-11-3
Alias CID-2011756, CID2011756

CID 2011756 is an ATP-competitive and specific PKD1 inhibitor.

CID 2011756

CID 2011756

🥰Excellent
Purity: 100%
Catalog No. T1863Alias CID-2011756, CID2011756Cas No. 638156-11-3
CID 2011756 is an ATP-competitive and specific PKD1 inhibitor.
Pack SizePriceAvailabilityQuantity
5 mg$40In Stock
10 mg$60In Stock
25 mg$106In Stock
50 mg$163In Stock
100 mg$247In Stock
200 mg$367In Stock
1 mL x 10 mM (in DMSO)$44In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
CID 2011756 is an ATP-competitive and specific PKD1 inhibitor.
Targets&IC50
PKD1:3.2 μM, PKD2:0.6 μM, PKD3:0.7 μM
Kinase Assay
Ub-PLA2 assay: Recombinant enzymes in 20 mM Tris-HCl, pH 8.0, 2 mM CaCl2 and 2 mM β-mercaptoethanol (DUB assay buffer) are preincubated with single doses or dose ranges of PR-619 or P22077 for 30 minutes in a 96 well plate before the addition of Ub-PLA2 and NBD C6-HPC. The liberation of a fluorescent product within the linear range of the assay is monitored at room temperature using a fluorescence plate reader. Vehicle (2%(v/v) DMSO) and 10 mM N-ethylmaleimide are included as controls. Where ≥60% inhibition is observed, EC50 values are determined using a sigmoidal dose response equation.
AliasCID-2011756, CID2011756
Chemical Properties
Molecular Weight396.87
FormulaC22H21ClN2O3
Cas No.638156-11-3
SmilesClc1cccc(c1)-c1ccc(o1)C(=O)Nc1ccc(CN2CCOCC2)cc1
Relative Density.1.297 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 15 mg/mL (37.8 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5197 mL12.5986 mL25.1972 mL125.9858 mL
5 mM0.5039 mL2.5197 mL5.0394 mL25.1972 mL
10 mM0.2520 mL1.2599 mL2.5197 mL12.5986 mL
20 mM0.1260 mL0.6299 mL1.2599 mL6.2993 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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