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CSN5i-3
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CSN5i-3
Catalog No. T10895Cas No. 2375740-98-8
CSN5i-3 is a novel potent oral and selective CSN5/Jab1 inhibitor that inhibits CSN-catalyzed Cul1 deneddylation with an IC50 value of 5.8 nM.CSN5i-3 exhibits anticancer activity, inhibits cell proliferation and induces apoptosis in human breast cancer cells.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $378 | In Stock | |
| 5 mg | $813 | In Stock | |
| 10 mg | $1,230 | In Stock | |
| 25 mg | $1,830 | In Stock | |
| 50 mg | $2,470 | In Stock | |
| 100 mg | $3,330 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $886 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | CSN5i-3 is a novel potent oral and selective CSN5/Jab1 inhibitor that inhibits CSN-catalyzed Cul1 deneddylation with an IC50 value of 5.8 nM.CSN5i-3 exhibits anticancer activity, inhibits cell proliferation and induces apoptosis in human breast cancer cells. |
| In vitro | CSN5i-3, by trapping CRLs in the neddylation state, effectively causes the inactivation of a specific subset of CRLs through the induction of degradation in their substrate recognition module.[1] |
| In vivo | CSN5i-3 exhibits a favorable pharmacokinetic profile, and its application results in the formation of cleaved PARP and cleaved caspase 3, indicating the initiation of apoptosis.[1] |
| Molecular Weight | 505.56 |
| Formula | C28H29F2N5O2 |
| Cas No. | 2375740-98-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (98.9 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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