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D-AP5

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Purity:100%

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COA LCMS HNMR

D-AP5

Catalog No. T10930Cas No. 79055-68-8

D-AP5 (D-APV) is a NMDA receptor antagonist.

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Pack Size	Price	Availability
1 mg	$30	In Stock
2 mg	$40	In Stock
5 mg	$64	In Stock
10 mg	$113	In Stock
25 mg	$239	In Stock
50 mg	$477	In Stock
1 mL x 10 mM (in DMSO)	$62	In Stock

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Product Introduction

Bioactivity

Description	D-AP5 (D-APV) is a NMDA receptor antagonist.
In vivo	D-AP5 is an NMDA receptor antagonist. Chronic intraventricular injection of D-AP5 can cause dose-dependent parallel damage to spatial learning and long-term enhancement (LTP) in vivo. When preventing spatial learning, the concentration of D-AP5 in the brain cannot cause any measurable sensorimotor disturbances. Compared with the test, D-AP5 infusion will cause a gradual decrease in swimming speed. D-AP5 causes sensorimotor disturbances in space tasks, but gradually deteriorates due to the inability of animals to learn. Rats treated with D-AP5 showed spatially dependent delay-dependent defects in the delayed matching placement protocol of the water maze.
Alias	D-APV, D-2-Amino-5-phosphonovaleric acid

Chemical Properties

Molecular Weight	197.13
Formula	C5H12NO5P
Cas No.	79055-68-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble)

H2O: 27.78 mg/mL (140.92 mM)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	5.0728 mL	25.3640 mL	50.7279 mL	253.6397 mL
5 mM	1.0146 mL	5.0728 mL	10.1456 mL	50.7279 mL
10 mM	0.5073 mL	2.5364 mL	5.0728 mL	25.3640 mL
20 mM	0.2536 mL	1.2682 mL	2.5364 mL	12.6820 mL
50 mM	0.1015 mL	0.5073 mL	1.0146 mL	5.0728 mL
100 mM	0.0507 mL	0.2536 mL	0.5073 mL	2.5364 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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