Shopping Cart
- Remove All
Your shopping cart is currently empty
DAMGO
Catalog No. T4351Cas No. 78123-71-4
Alias RX-783006, Dagol, DAGO
DAMGO (DAGO) is an opioid receptor agonist with the ability to affect the locomotive activity in rodents. Possible analgesic agent due to μ-opiod receptor interaction.
DAMGO
Catalog No. T4351Alias RX-783006, Dagol, DAGOCas No. 78123-71-4
DAMGO (DAGO) is an opioid receptor agonist with the ability to affect the locomotive activity in rodents. Possible analgesic agent due to μ-opiod receptor interaction.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $43 | In Stock | |
| 2 mg | $55 | In Stock | |
| 5 mg | $79 | In Stock | |
| 10 mg | $143 | In Stock | |
| 25 mg | $297 | In Stock | |
| 50 mg | $445 | In Stock | |
| 100 mg | $656 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $90 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "DAMGO"
Mianserin hydrochloride
ORG GB-94 HCl, Org GB 94, Mianserin HCl
T078321535-47-7
Mianserin hydrochloride (Org GB 94) is a tetracyclic compound with antidepressant properties that blocks alpha-adrenergic, histamine H1, and certain serotonin receptors; it may cause drowsiness and hematological issues.
- $30
Size
QTY
Mirtazapine
Org3770, 6-Azamianserin
T013785650-52-8
Mirtazapine (6-Azamianserin) is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury.
- $34
Size
QTY
Docusate sodium
Dioctyl sulfosuccinate sodium salt, Constonate, Bis(2-ethylhexyl) sulfosuccinate sodium salt, Aerosol OT
T0929577-11-7
Docusate sodium (Aerosol OT) is an orally available, over-the-counter laxative and stool softener used to treat or prevent constipation. Docusate has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury with jaundice.
- $36
Size
QTY
Progesterone
Cited
Pregn-4-ene-3,20-dione
T047857-83-0
Progesterone (Pregn-4-ene-3,20-dione) is the major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production.
- $38
Size
QTY
Cited(-)-Menthol
Menthomenthol, Menthacamphor, L-Menthol, Levomenthol
T14072216-51-5
(-)-Menthol (Levomenthol) is a levo isomer of menthol, an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties. When added to pharmaceuticals and foods, menthol functions as a fortifier for peppermint flavors. It also has a counterirritant effect on skin and mucous membranes, thereby producing a local analgesic or anesthetic effect.
- $31
Size
QTY
Naltrexone hydrochloride
Trexan, Naltrexone HCl, Depade, Antaxone
T096316676-29-2
Naltrexone hydrochloride (Naltrexone HCl) is a synthetic opioid antagonist used in the prevention of relapse of opiate addiction and alcoholism.
- $50
Size
QTY
Trimebutine
Mebutin
T091839133-31-8
Trimebutine (Mebutin) is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu-opioid agonist effects. It is marketed for the treatment of irritable bowel syndrome (IBS) and lower gastrointestinal tract motility disorders, with IBS being one of the most common multifactorial GI disorders. It is used to restore normal bowel function and is commonly present in pharmaceutical mixtures as trimebutine maleate salt form. Trimebutine is not an FDA-Approved/Clinical drug, but it is available in Canada and several other international countries.
- $30
Size
QTY
Amentoflavone Cited
Didemethyl-ginkgetin, Amenthoflavone, 3',8''-Biapigenin
T34171617-53-4
Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhibitor of human cathepsin B. It has antimalarial activity in trials significant affinities towards the Delta-1, kappa opioid receptors (as an antagonist) and binds to benzodiazepine receptors. Amentoflavone may be a potential lead for a new type of anti-inflammatory agents having the dual inhibitory activity of group II phospholipase A2 and cyclooxygenase. Amentoflavone and quercetin differentially exerted suppression of PGE2 biosynthesis via downregulation of COX-2/iNOS expression.
- $30
Size
QTY
CitedMatrine
α-Matrine, Vegard, Matrinium, Matridin-15-one, (+)-Matrine
T2870519-02-8
Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.
- $36
Size
QTY
Bevenopran
CB-5945, ADL-5945
T14551676500-67-7
Bevenopran (CB-5945) is a peripheral antagonist of μ-opioid receptor and can be used in studies about the treatment of opioid-induced bowel dysfunction.
- $98
Size
QTY
Select Batch
Purity:99.92%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | DAMGO (DAGO) is an opioid receptor agonist with the ability to affect the locomotive activity in rodents. Possible analgesic agent due to μ-opiod receptor interaction. |
| Targets&IC50 | μ opioid receptor (Native):3.46±0.84 nM (Kd) |
| In vivo | (1) DAMGO inhibits GABAergic inputs in VTA-DA neurons at presynaptic sites; (2) effect of DAMGO on GABAergic inputs in VTA-DA neurons is inhibited by potassium channel blocker 4-aminopyridine (4-AP) and Gi protein inhibitor N-ethyl maleimide (NEM); (3) phospholipase A2 (PLA2) does not mediate the effect of DAMGO on GABAergic inputs in VTA-DA neurons, but mediates it in the periaqueductal gray (PAG); (4) multiple downstream signaling molecules of l receptors do not mediate the effect of DAMGO on GABAergic inputs in VTA-DA neurons. These results suggest that DAMGO depresses inhibitory synaptic transmission via l receptor-Gi protein-Kv channel pathway in VTA-DA neurons, but via l receptor-PLA2 pathway in PAG |
| Alias | RX-783006, Dagol, DAGO |
| Molecular Weight | 513.59 |
| Formula | C26H35N5O6 |
| Cas No. | 78123-71-4 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 33.33 mg/mL (64.90 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy DAMGO | purchase DAMGO | DAMGO cost | order DAMGO | DAMGO chemical structure | DAMGO in vivo | DAMGO formula | DAMGO molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.