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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $133 | In Stock | |
5 mg | $335 | In Stock | |
10 mg | $537 | In Stock | |
25 mg | $787 | In Stock | |
50 mg | $1,070 | In Stock | |
100 mg | $1,430 | In Stock | |
1 mL x 10 mM (in DMSO) | $345 | In Stock |
Description | Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling. |
Targets&IC50 | HIV-1:0.38 μM (IC50), H+-ATPase (vacuolar type):17 nM (IC50) |
In vitro | The in vitro inhibitory effects of these compounds were evaluated on the production of nitric oxide (NO) and cytokines (tumor necrosis factor (TNF)-alpha and interleukin (IL)-12), from LPS/IFN-gamma activated murine peritoneal macrophages. The results indicated that the 50% inhibition concentration (IC(50)) values of NO production from activated peritoneal macrophages by compounds 1-4 were 100, 25, 12.5 and 50 microM, respectively. In parallel, these dilutions were approximately inhibited in a similar manner to that observed for cytokines (TNF-alpha, and IL-12) production. On the other hand, at 100 microM concentration compounds 3 and 4 showed 50% inhibition of NO production from peritoneal macrophages that had been pre-activated with LPS/IFN-gamma for 24h, whereas compounds 1 and 2 inhibited only about 20 and 10%, respectively. |
Molecular Weight | 380.35 |
Formula | C21H16O7 |
Cas No. | 22055-22-7 |
Storage | keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 3.8 mg/mL (10 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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