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DS-1971a
Catalog No. T9685Cas No. 1450595-86-4
DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.
DS-1971a
Catalog No. T9685Cas No. 1450595-86-4
DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $81 | In Stock | |
| 5 mg | $173 | In Stock | |
| 10 mg | $273 | In Stock | |
| 25 mg | $452 | In Stock | |
| 50 mg | $636 | In Stock | |
| 100 mg | $858 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $178 | In Stock |
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Purity:99.66%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects. |
| Targets&IC50 | Nav1.7 (mouse):59.4 nM, Nav1.7 (human):22.8 nM |
| In vitro | DS-1971a showed high NaV1.7 inhibitory potency in vitro. The IC50 values are of 22.8 nM for hNaV1.7 and 59.4 mM for mNaV1.7[1]. |
| In vivo | DS-1971a (0.1-1 mg/kg; p.o.) shows mitigated thermal hyperalgesia in a dose-dependent manner in partial sciatic nerve ligation (PSL) mice with ED50 of 0.32 mg/kg[1]. |
| Molecular Weight | 465.93 |
| Formula | C20H21ClFN5O3S |
| Cas No. | 1450595-86-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (214.62 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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