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DS-1971a

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COA HNMR LCMS

DS-1971a

Catalog No. T9685Cas No. 1450595-86-4

DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.

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Pack Size	Price	Availability
1 mg	$135	In Stock
5 mg	$289	In Stock
10 mg	$455	In Stock
25 mg	$753	In Stock
50 mg	$1,060	In Stock
100 mg	$1,430	In Stock
1 mL x 10 mM (in DMSO)	$296	In Stock

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Product Introduction

Bioactivity

Description	DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.
In vitro	DS-1971a showed high NaV1.7 inhibitory potency in vitro. The IC50 values are of 22.8 nM for hNaV1.7 and 59.4 mM for mNaV1.7[1].
In vivo	DS-1971a (0.1-1 mg/kg; p.o.) shows mitigated thermal hyperalgesia in a dose-dependent manner in partial sciatic nerve ligation (PSL) mice with ED50 of 0.32 mg/kg[1].

Chemical Properties

Molecular Weight	465.93
Formula	C20H21ClFN5O3S
Cas No.	1450595-86-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (214.62 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1462 mL	10.7312 mL	21.4625 mL	107.3123 mL
5 mM	0.4292 mL	2.1462 mL	4.2925 mL	21.4625 mL
10 mM	0.2146 mL	1.0731 mL	2.1462 mL	10.7312 mL
20 mM	0.1073 mL	0.5366 mL	1.0731 mL	5.3656 mL
50 mM	0.0429 mL	0.2146 mL	0.4292 mL	2.1462 mL
100 mM	0.0215 mL	0.1073 mL	0.2146 mL	1.0731 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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