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DSM265 (PfSPZ) is a dihydroorotic acid dehydrogenase inhibitor with antimalarial activity (IC50: 8.9 nM).DSM265 inhibits the growth of Pf3D7 parasites and can be used for the treatment and prophylaxis of malaria infections.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $30 | In Stock | |
5 mg | $64 | In Stock | |
10 mg | $89 | In Stock | |
1 mL x 10 mM (in DMSO) | $68 | In Stock |
Description | DSM265 (PfSPZ) is a dihydroorotic acid dehydrogenase inhibitor with antimalarial activity (IC50: 8.9 nM).DSM265 inhibits the growth of Pf3D7 parasites and can be used for the treatment and prophylaxis of malaria infections. |
Targets&IC50 | P. falciparum (3D7 parasites):4.3 nM (EC50), PfDHODH:8.9 nM |
In vivo | In NOD-scid IL-2Rγnull (NSG) mice (23-36 g), DSM265 (0.5 - 75 mg/kg; oral administration; twice daily; for 4 days) exhibited potent antimalarial activity[2]. |
Alias | PfSPZ |
Molecular Weight | 415.33 |
Formula | C14H12F7N5S |
Cas No. | 1282041-94-4 |
Smiles | Cc1cc(Nc2ccc(cc2)S(F)(F)(F)(F)F)n2nc(nc2n1)C(C)(F)F |
Relative Density. | no data available |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: < 0.1 mg/mL (insoluble.) Ethanol: 5 mg/mL (12.04 mM), Sonication is recommended. DMSO: 30 mg/mL (72.23 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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