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Enpp/Carbonic anhydrase-IN-2

🥰Excellent
Catalog No. T77631Cas No. 2883495-39-2

Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.07, 0.74, 0.33, 0.68, respectively.Enpp/Carbonic anhydrase-IN-2 induced apoptosis.Enpp/Carbonic anhydrase-IN-2 has antiproliferative activity against cancer cells and low cytotoxicity against normal cells.

Enpp/Carbonic anhydrase-IN-2

Enpp/Carbonic anhydrase-IN-2

🥰Excellent
Purity: 99.13%
Catalog No. T77631Cas No. 2883495-39-2
Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.07, 0.74, 0.33, 0.68, respectively.Enpp/Carbonic anhydrase-IN-2 induced apoptosis.Enpp/Carbonic anhydrase-IN-2 has antiproliferative activity against cancer cells and low cytotoxicity against normal cells.
Pack SizePriceAvailabilityQuantity
1 mg$93 In Stock
5 mg$230 In Stock
10 mg$372 In Stock
25 mg$626 In Stock
50 mg$892 In Stock
100 mg$1,220 In Stock
500 mg$2,430 In Stock
1 mL x 10 mM (in DMSO)$245 In Stock
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Purity:99.13%
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Product Introduction

Bioactivity
Description
Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.07, 0.74, 0.33, 0.68, respectively.Enpp/Carbonic anhydrase-IN-2 induced apoptosis.Enpp/Carbonic anhydrase-IN-2 has antiproliferative activity against cancer cells and low cytotoxicity against normal cells.
Targets&IC50
NPP3:0.74 μM, NPP2:1.07 μM, NPP1:1.13 μM, CA XII:0.68 μM, CA IX:0.33 μM
In vitro
Enpp/Carbonic anhydrase-IN-2 (compound 1i) (0-2 µM) exhibits low cytotoxicity against normal breast epithelial cells (HME1) and normal skin fibroblast cells (F180) with IC50s > 50 µM.[1] Enpp/Carbonic anhydrase-IN-2 (0-100 µM) inhibits the growth of various cancer cells, showing IC50s of 0.58, 0.58, 0.63, 0.42, 0.20, 0.72, 0.41, 0.76, 0.94, 0.28, 0.49, 0.59, and 0.83 µM for K-562, COLO 205, HCT-116, HCT-15, HT29, KM12, SW-620, SF-539, NCI/ADR-RES, A498, PC-3, MCF7, and T-47D cells, respectively.[1] Additionally, Enpp/Carbonic anhydrase-IN-2 (0.58, 1.16 µM) induces apoptosis in a dose-dependent manner in K-562 cells.[1]
Chemical Properties
Molecular Weight429.5
FormulaC23H24FNO4S
Cas No.2883495-39-2
SmilesC(NC1=CC=C(OS(=O)(=O)C2=CC=C(F)C=C2)C=C1)(=O)C34CC5CC(C3)CC(C4)C5
Relative Density.no data available
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 40 mg/mL (93.13 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3283 mL11.6414 mL23.2829 mL116.4144 mL
5 mM0.4657 mL2.3283 mL4.6566 mL23.2829 mL
10 mM0.2328 mL1.1641 mL2.3283 mL11.6414 mL
20 mM0.1164 mL0.5821 mL1.1641 mL5.8207 mL
50 mM0.0466 mL0.2328 mL0.4657 mL2.3283 mL

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