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Enpp/Carbonic anhydrase-IN-2

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Purity:99.13%

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COA HNMR HPLC

Enpp/Carbonic anhydrase-IN-2

Catalog No. T77631Cas No. 2883495-39-2

Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.07, 0.74, 0.33, 0.68, respectively.Enpp/Carbonic anhydrase-IN-2 induced apoptosis.Enpp/Carbonic anhydrase-IN-2 has antiproliferative activity against cancer cells and low cytotoxicity against normal cells.

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Pack Size	Price	Availability
1 mg	$93	In Stock
5 mg	$230	In Stock
10 mg	$372	In Stock
25 mg	$626	In Stock
50 mg	$892	In Stock
100 mg	$1,220	In Stock
500 mg	$2,430	In Stock
1 mL x 10 mM (in DMSO)	$245	In Stock

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Product Introduction

Bioactivity

Description

In vitro

Enpp/Carbonic anhydrase-IN-2 (compound 1i) (0-2 µM) shows low cytotoxic against normal breast epithelial cells (HME1) and normal skin fibroblast cells (F180) with IC50s of > 50 μM.[1]
Enpp/Carbonic anhydrase-IN-2 (0-100 µM) inhibits some cancer cells growth with IC50s of 0.58, 0.58, 0.63, 0.42, 0.20, 0.72, 0.41, 0.76, 0.94, 0.28, 0.49, 0.59, 0.83 µM for K-562, COLO 205, HCT-116, HCT-15, HT29, KM12, SW-620, SF-539, NCI/ADR-RES, A498, PC-3, MCF7, T-47D cells, respectively.[1]
Enpp/Carbonic anhydrase-IN-2 (0.58, 1.16 µM) induces apoptosis in a dose-dependent manner at K-562 cells.[1]

Chemical Properties

Molecular Weight	429.5
Formula	C23H24FNO4S
Cas No.	2883495-39-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (93.13 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3283 mL	11.6414 mL	23.2829 mL	116.4144 mL
5 mM	0.4657 mL	2.3283 mL	4.6566 mL	23.2829 mL
10 mM	0.2328 mL	1.1641 mL	2.3283 mL	11.6414 mL
20 mM	0.1164 mL	0.5821 mL	1.1641 mL	5.8207 mL
50 mM	0.0466 mL	0.2328 mL	0.4657 mL	2.3283 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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