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Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.07, 0.74, 0.33, 0.68, respectively.Enpp/Carbonic anhydrase-IN-2 induced apoptosis.Enpp/Carbonic anhydrase-IN-2 has antiproliferative activity against cancer cells and low cytotoxicity against normal cells.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $93 | In Stock | |
5 mg | $230 | In Stock | |
10 mg | $372 | In Stock | |
25 mg | $626 | In Stock | |
50 mg | $892 | In Stock | |
100 mg | $1,220 | In Stock | |
500 mg | $2,430 | In Stock | |
1 mL x 10 mM (in DMSO) | $245 | In Stock |
Description | Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.07, 0.74, 0.33, 0.68, respectively.Enpp/Carbonic anhydrase-IN-2 induced apoptosis.Enpp/Carbonic anhydrase-IN-2 has antiproliferative activity against cancer cells and low cytotoxicity against normal cells. |
Targets&IC50 | NPP3:0.74 μM, NPP2:1.07 μM, NPP1:1.13 μM, CA XII:0.68 μM, CA IX:0.33 μM |
In vitro | Enpp/Carbonic anhydrase-IN-2 (compound 1i) (0-2 µM) exhibits low cytotoxicity against normal breast epithelial cells (HME1) and normal skin fibroblast cells (F180) with IC50s > 50 µM.[1] Enpp/Carbonic anhydrase-IN-2 (0-100 µM) inhibits the growth of various cancer cells, showing IC50s of 0.58, 0.58, 0.63, 0.42, 0.20, 0.72, 0.41, 0.76, 0.94, 0.28, 0.49, 0.59, and 0.83 µM for K-562, COLO 205, HCT-116, HCT-15, HT29, KM12, SW-620, SF-539, NCI/ADR-RES, A498, PC-3, MCF7, and T-47D cells, respectively.[1] Additionally, Enpp/Carbonic anhydrase-IN-2 (0.58, 1.16 µM) induces apoptosis in a dose-dependent manner in K-562 cells.[1] |
Molecular Weight | 429.5 |
Formula | C23H24FNO4S |
Cas No. | 2883495-39-2 |
Smiles | C(NC1=CC=C(OS(=O)(=O)C2=CC=C(F)C=C2)C=C1)(=O)C34CC5CC(C3)CC(C4)C5 |
Relative Density. | no data available |
Storage | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 40 mg/mL (93.13 mM), Sonication is recommended. ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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