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Enpp/Carbonic anhydrase-IN-2
🥰Excellent
Catalog No. T77631Cas No. 2883495-39-2
Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.07, 0.74, 0.33, 0.68, respectively.Enpp/Carbonic anhydrase-IN-2 induced apoptosis.Enpp/Carbonic anhydrase-IN-2 has antiproliferative activity against cancer cells and low cytotoxicity against normal cells.
Enpp/Carbonic anhydrase-IN-2
🥰Excellent
Purity: 99.13%
Catalog No. T77631Cas No. 2883495-39-2
Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.07, 0.74, 0.33, 0.68, respectively.Enpp/Carbonic anhydrase-IN-2 induced apoptosis.Enpp/Carbonic anhydrase-IN-2 has antiproliferative activity against cancer cells and low cytotoxicity against normal cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $56 | In Stock | |
| 5 mg | $138 | In Stock | |
| 10 mg | $223 | In Stock | |
| 25 mg | $376 | In Stock | |
| 50 mg | $535 | In Stock | |
| 100 mg | $732 | In Stock | |
| 200 mg | $985 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $147 | In Stock |
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Purity:99.13%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.07, 0.74, 0.33, 0.68, respectively.Enpp/Carbonic anhydrase-IN-2 induced apoptosis.Enpp/Carbonic anhydrase-IN-2 has antiproliferative activity against cancer cells and low cytotoxicity against normal cells. |
| Targets&IC50 | NPP3:0.74 μM, CA IX:0.33 μM, NPP1:1.13 μM, NPP2:1.07 μM, CA XII:0.68 μM |
| In vitro | Enpp/Carbonic anhydrase-IN-2 (compound 1i) (0-2 µM) exhibits low cytotoxicity against normal breast epithelial cells (HME1) and normal skin fibroblast cells (F180) with IC50s > 50 µM.[1] Enpp/Carbonic anhydrase-IN-2 (0-100 µM) inhibits the growth of various cancer cells, showing IC50s of 0.58, 0.58, 0.63, 0.42, 0.20, 0.72, 0.41, 0.76, 0.94, 0.28, 0.49, 0.59, and 0.83 µM for K-562, COLO 205, HCT-116, HCT-15, HT29, KM12, SW-620, SF-539, NCI/ADR-RES, A498, PC-3, MCF7, and T-47D cells, respectively.[1] Additionally, Enpp/Carbonic anhydrase-IN-2 (0.58, 1.16 µM) induces apoptosis in a dose-dependent manner in K-562 cells.[1] |
| Molecular Weight | 429.5 |
| Formula | C23H24FNO4S |
| Cas No. | 2883495-39-2 |
| Smiles | C(NC1=CC=C(OS(=O)(=O)C2=CC=C(F)C=C2)C=C1)(=O)C34CC5CC(C3)CC(C4)C5 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (93.13 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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