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Esonarimod
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Purity:99.83%
Esonarimod
Catalog No. T4279Cas No. 101973-77-7
Esonarimod (KE-298) is an antirheumatic drug designed to alleviate symptoms associated with rheumatoid arthritis.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $40 | In Stock | |
| 10 mg | $56 | In Stock | |
| 25 mg | $113 | In Stock | |
| 50 mg | $189 | In Stock | |
| 100 mg | $297 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $44 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Esonarimod (KE-298) is an antirheumatic drug designed to alleviate symptoms associated with rheumatoid arthritis. |
| In vitro | The IC50 of Esonarimod is 117.5 μg/mL. In RAW264.7 cells, Esonarimod (KE-298) (10 to 300 μg/mL) suppresses the production of NO in a dose-dependent manner. |
| In vivo | After repeated oral administration of Esonarimod (14C-KE-298), the radioactivity rapidly decreases with no accumulation observed. |
| Kinase Assay | To test enzyme activity of NOS, the lysate from RAW264.7 cells (a protein concentration of 37.5 μg/200 μL) is incubated for 3 h at 37°C with 100 mM of L-arginine in the presence of Esonarimod (KE-298) and the conversion of L-arginine to nitrite is monitored. |
| Cell Research | For in vitro experiment, Esonarimod (KE-298) is dissolved in ethanol and diluted with culture medium or distilled water.RAW264.7 cells are used in this study. For NO production, RAW264.7 cells [2×105/0.2 mL of RPMI-1640 supplemented by 10% heat inactivated fetal bovine serum (FBS), penicillin G (100 U/mL), and streptomycin (100 μg/mL)] are stimulated with 100 ng/mL of Escherichia coli 026:B6 lipopolysaccharide in the presence of Esonarimod (KE-298) (0, 10, 30, 100, 200, 300 μg/mL) in 96 well plates and incubated 24 h at 37°C in an atmosphere of 5% CO2 in air. After incubation, the supernatants are collected and assayed for nitrite (NO2-) instead of NO[1]. |
| Animal Research | Seven-week-old male Wistar rats is administered Esonarimod (5 mg/kg once daily) orally by gastric intubation. |
| Alias | KE-298 |
| Molecular Weight | 280.34 |
| Formula | C14H16O4S |
| Cas No. | 101973-77-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (214.03 mM)  | |||||||||||||||||||||||||||||||||||
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