Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Eugenol

🥰Excellent
Catalog No. T1297Cas No. 97-53-0
Alias Eugenic acid, Allylguaiacol, 4-Allylguaiacol, 4-Allyl-2-methoxyphenol

Eugenol (Allylguaiacol) is a Standardized Chemical Allergen. The physiologic effect of eugenol is by means of Increased Histamine Release and Cell-mediated Immunity.

Eugenol

Eugenol

🥰Excellent
Purity: 99.72%
Catalog No. T1297Alias Eugenic acid, Allylguaiacol, 4-Allylguaiacol, 4-Allyl-2-methoxyphenolCas No. 97-53-0
Eugenol (Allylguaiacol) is a Standardized Chemical Allergen. The physiologic effect of eugenol is by means of Increased Histamine Release and Cell-mediated Immunity.
Pack SizePriceAvailabilityQuantity
500 mg$29In Stock
1 mL x 10 mM (in DMSO)$50In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "Eugenol"

Select Batch
Purity:99.72%
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
Eugenol (Allylguaiacol) is a Standardized Chemical Allergen. The physiologic effect of eugenol is by means of Increased Histamine Release and Cell-mediated Immunity.
In vitro
Eugenol has antiproliferative effects in diverse cancer cell lines as well as in B16 melanoma xenograft model. Eugenol induces apoptosis in various cancer cells, including mast cells, melanoma cells and HL-60 leukemia cells. Eugenol at low dose (2 μM) has specific toxicity against different breast cancer cells. This killing effect is mediated mainly through inducing the internal apoptotic pathway and strong down-regulation of E2F1 and its downstream antiapoptosis target survivin, independently of the status of p53 and ERα. Eugenol inhibits also several other breast cancer related oncogenes, such as NF-κB and cyclin D1. Moreover, eugenol up-regulates the versatile cyclin-dependent kinase inhibitor p21WAF1 protein, and inhibits the proliferation of breast cancer cells in a p53-independent manner[2].
In vivo
Eugenol inhibits the proliferation of breast cancer cells in vivo as well. The inhibitory effect of eugenol on onco-proteins is also observed in vivo in tumor xenografts[2]. Eugenol (0.2, 1.0, 5.0 or 25 mg/kg) when given orally at three different times in relation to the time of CCl4 dosing (i.p administration of 0.4 mg/kg), i.e. prior to (-1 hr), along with (0 hr) or after (+ 3 hrs), prevents significantly the rise in SGOT(Serum glutamic-oxaloacetic transaminase) activity, lipid peroxidation as well as liver necrosis. The protective effect is more evident at 1 mg and 5 mg eugenol doses than at 0.2 and 25 mg does. However, the decrease in microsomal G-6-pase activity by CCl4 treatment is not prevented by eugenol suggesting that the damage to endoplasmic reticulum is not protected[3].
Cell Research
Cells are seeded into 96-well plates and incubated overnight. The medium is replaced with fresh one containing the desired concentrations of eugenol. After 20 hrs, 10 μl of the WST-1 reagent is added to each well and the plates are incubated for 4 hrs at 37°C. The amount of formazan is quantified using ELISA reader at 450 nm of absorbance.(Only for Reference)
AliasEugenic acid, Allylguaiacol, 4-Allylguaiacol, 4-Allyl-2-methoxyphenol
Chemical Properties
Molecular Weight164.2
FormulaC10H12O2
Cas No.97-53-0
SmilesO(C)C1=CC(CC=C)=CC=C1O
Relative Density.1.067 g/cm3 at 25℃ (lit.)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 65 mg/mL (395.85 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM6.0901 mL30.4507 mL60.9013 mL304.5067 mL
5 mM1.2180 mL6.0901 mL12.1803 mL60.9013 mL
10 mM0.6090 mL3.0451 mL6.0901 mL30.4507 mL
20 mM0.3045 mL1.5225 mL3.0451 mL15.2253 mL
50 mM0.1218 mL0.6090 mL1.2180 mL6.0901 mL
100 mM0.0609 mL0.3045 mL0.6090 mL3.0451 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy Eugenol | purchase Eugenol | Eugenol cost | order Eugenol | Eugenol chemical structure | Eugenol in vivo | Eugenol in vitro | Eugenol formula | Eugenol molecular weight