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Gemigliptin

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COA HPLC HNMR

Gemigliptin

Catalog No. T7369Cas No. 911637-19-9

Gemigliptin (LC15-0444) is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.)

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Pack Size	Price	Availability
2 mg	$34	In Stock
5 mg	$55	In Stock
10 mg	$89	In Stock
25 mg	$159	In Stock
50 mg	$272	In Stock
100 mg	$428	In Stock
500 mg	$969	In Stock
1 mL x 10 mM (in DMSO)	$81	In Stock

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Product Introduction

Bioactivity

Description	Gemigliptin (LC15-0444) is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.)
In vitro	Gemigliptin attenuated vascular calcification and osteogenic trans-differentiation in vascular smooth muscle cells via multiple steps including downregulation of PiT-1 expression and suppression of reactive oxygen species generation, phospho-PI3K/AKT, and the Wnt signaling pathway[1].Gemigliptin treatment attenuated phosphorylated nuclear factor-κB levels, which had been increased in the UUO kidney as well as in TGF-β-treated cultured renal cells[2].
Cell Research	Using immunohistochemical and Western blot analysis, Quantitated components of the NLRP3 inflammasome in kidneys with and without gemigliptin treatment, and in vitro in human kidney tubular epithelial human renal proximal tubule cells (HK-2) cells, further analyzed the effect of gemigliptin on transforming growth factor-β (TGF-β)-stimulated production of profibrotic proteins[2].
Alias	LC15-0444

Chemical Properties

Molecular Weight	489.36
Formula	C18H19F8N5O2
Cas No.	911637-19-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 122.5 mg/mL (250.33 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0435 mL	10.2174 mL	20.4349 mL	102.1743 mL
5 mM	0.4087 mL	2.0435 mL	4.0870 mL	20.4349 mL
10 mM	0.2043 mL	1.0217 mL	2.0435 mL	10.2174 mL
20 mM	0.1022 mL	0.5109 mL	1.0217 mL	5.1087 mL
50 mM	0.0409 mL	0.2043 mL	0.4087 mL	2.0435 mL
100 mM	0.0204 mL	0.1022 mL	0.2043 mL	1.0217 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc