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Golexanolone
🥰Excellent
Catalog No. T25458Cas No. 2089238-18-4
Alias GR-3027, Golexanolonum, Golexanolona
Golexanolone (Golexanolona) is a novel GABA-A receptor-modulating steroid antagonist that reduces peripheral inflammation and neuroinflammation and improves cognitive and motor function in rats with chronic hyperammonemia, and may be used to study hepatic encephalopathy.
Golexanolone
🥰Excellent
Purity: 99.98%
Catalog No. T25458Alias GR-3027, Golexanolonum, GolexanolonaCas No. 2089238-18-4
Golexanolone (Golexanolona) is a novel GABA-A receptor-modulating steroid antagonist that reduces peripheral inflammation and neuroinflammation and improves cognitive and motor function in rats with chronic hyperammonemia, and may be used to study hepatic encephalopathy.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | In Stock | |
| 5 mg | $722 | In Stock | |
| 10 mg | $987 | In Stock | |
| 25 mg | $1,520 | In Stock | |
| 50 mg | $1,980 | In Stock |
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CitedSelect Batch
Purity:99.98%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Golexanolone (Golexanolona) is a novel GABA-A receptor-modulating steroid antagonist that reduces peripheral inflammation and neuroinflammation and improves cognitive and motor function in rats with chronic hyperammonemia, and may be used to study hepatic encephalopathy. |
| In vitro | In the absence of agonist (i.e., GABA, 0), the THDOC-mediated outward current excursion was significantly reduced when Golexanolone(GR3027) concentration was incrementally increased (0.03-3 µM, Fig. 2A), with an IC50 = 344 nM and Imax -33%. In addition, analysis of the AUC and peak current amplitude of the GABA-mediated response showed a concentration-dependent decrease in both parameters (IC50 = 341 nM, Imax -35% for AUC; IC50 = 563 nM, Imax -37% for peak current amplitude; n = 4-14, 95% confidence intervals;) The data suggest that the effects of Golexanolone(GR3027) on the THDOC-mediated α5β3γ2L GABAA channel activation.[2] |
| In vivo | In a toxicity study using doses of 50 and 100 mg/kg/day to evaluate oral administration of Golexanolone(GR3027) in rats, no toxicity was observed at 100 mg/kg/day.[1] |
| Alias | GR-3027, Golexanolonum, Golexanolona |
| Molecular Weight | 329.48 |
| Formula | C21H31NO2 |
| Cas No. | 2089238-18-4 |
| Smiles | C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)\C(=N\O)\CC4)[H])(CC[C@]1(C[C@@](C#C)(O)CC2)[H])[H])[H] |
| Relative Density. | 1.22 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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