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GSK0660

Catalog No. T2674Cas No. 1014691-61-2

GSK0660 is an antagonist and inverse agonist of PPARβ/δ.

GSK0660

GSK0660

Purity: 100%
Catalog No. T2674Cas No. 1014691-61-2
GSK0660 is an antagonist and inverse agonist of PPARβ/δ.
Pack SizePriceAvailabilityQuantity
2 mg$39In Stock
5 mg$63In Stock
10 mg$106In Stock
25 mg$195In Stock
50 mg$388In Stock
100 mg$577In Stock
500 mg$1,260In Stock
1 mL x 10 mM (in DMSO)$63In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
GSK0660 is an antagonist and inverse agonist of PPARβ/δ.
Targets&IC50
PPARβ/δ:155 nM
Kinase Assay
Human astrocytoma cells, 1321N1, are grown to stably express rat P2X7, human P2X4, P2X2a, P2X2/3, P2X1, P2Y1?and P2Y2 recombinant receptors. Agonist, BzATP, 2,3-O-(4-ben-zoylbenzoyl)-ATP or ATP-induced changes in intracellular Ca2+?concentrations are assessed in all of the cell lines using the Ca2+?chelating dye, Fluo-4, in conjunction with a Fluorometric Imaging Plate Reader. The cells are plated out the day before the experiment onto poly-D-lysine-coated black 96 well plates. After the agonist addition, changes in intracellular Ca2+ concentrations are recorded, per second, for 3 min. Ligands are tested at 11 half-log concentrations from 10-10 to 10-4 M. BzATP or ATP concentrations corresponds to the EC70?values for each receptor to enable comparison of antagonist potencies across the multiple P2 receptor subtypes. A 438079 is added to the cell plate and ?uorescence data are collected for 3 min before the addition of agonist, subsequently, data are then collected for another 2 min. The pEC50 or pIC50 values are derived from a single curve ?t.
Chemical Properties
Molecular Weight418.49
FormulaC19H18N2O5S2
Cas No.1014691-61-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 4.18 mg/mL (10 mM)
DMSO: 50 mg/mL (119.48 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.3895 mL11.9477 mL23.8954 mL119.4772 mL
5 mM0.4779 mL2.3895 mL4.7791 mL23.8954 mL
10 mM0.2390 mL1.1948 mL2.3895 mL11.9477 mL
DMSO
1mg5mg10mg50mg
20 mM0.1195 mL0.5974 mL1.1948 mL5.9739 mL
50 mM0.0478 mL0.2390 mL0.4779 mL2.3895 mL
100 mM0.0239 mL0.1195 mL0.2390 mL1.1948 mL

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