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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $47 | In Stock | |
5 mg | $147 | In Stock | |
10 mg | $228 | In Stock | |
25 mg | $455 | In Stock | |
50 mg | $657 | In Stock | |
100 mg | $918 | In Stock | |
500 mg | $1,830 | In Stock | |
1 mL x 10 mM (in DMSO) | $162 | In Stock |
Description | GV-58 is a selective N- and P/Q-type Ca2+ channels agonist (EC50: 7.21/8.81 uM for N-type/P-Q-type Ca2+ channel). The inhibitory of GV-58 is 20-fold fewer for CDK kinases activity. |
In vitro | In comparison with the parent molecule, (R)-roscovitine, GV-58 has a 20-fold less potent cyclin-dependent kinase antagonist effect, a 3- to 4-fold more potent Ca2+ channel agonist effect, and 4-fold higher efficacy as a Ca2+ channel agonist. GV-58 had no agonist activity (up to 100 μm) on the L-type α-subunit we tested (Cav1.3). |
Molecular Weight | 374.5 |
Formula | C18H26N6OS |
Cas No. | 1402821-41-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 90 mg/mL (240.32 mM) Methanol: 55 mg/mL (146.86 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/Methanol
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