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GV-58

🥰Excellent
Catalog No. T11517Cas No. 1402821-41-3

GV-58 is a selective N- and P/Q-type Ca2+ channels agonist (EC50: 7.21/8.81 uM for N-type/P-Q-type Ca2+ channel). The inhibitory of GV-58 is 20-fold fewer for CDK kinases activity.

GV-58

GV-58

🥰Excellent
Purity: 97.36%
Catalog No. T11517Cas No. 1402821-41-3
GV-58 is a selective N- and P/Q-type Ca2+ channels agonist (EC50: 7.21/8.81 uM for N-type/P-Q-type Ca2+ channel). The inhibitory of GV-58 is 20-fold fewer for CDK kinases activity.
Pack SizePriceAvailabilityQuantity
1 mg$47In Stock
5 mg$147In Stock
10 mg$228In Stock
25 mg$455In Stock
50 mg$657In Stock
100 mg$918In Stock
500 mg$1,830In Stock
1 mL x 10 mM (in DMSO)$162In Stock
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Purity:97.36%
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Product Introduction

Bioactivity
Description
GV-58 is a selective N- and P/Q-type Ca2+ channels agonist (EC50: 7.21/8.81 uM for N-type/P-Q-type Ca2+ channel). The inhibitory of GV-58 is 20-fold fewer for CDK kinases activity.
Targets&IC50
Ca2+ channel, N-type:7.21 uM, Ca2+ channel, P/Q-type:8.81 uM
In vitro
In comparison with the parent molecule, (R)-roscovitine, GV-58 has a 20-fold less potent cyclin-dependent kinase antagonist effect, a 3- to 4-fold more potent Ca2+ channel agonist effect, and 4-fold higher efficacy as a Ca2+ channel agonist. GV-58 had no agonist activity (up to 100 μm) on the L-type α-subunit we tested (Cav1.3).
Chemical Properties
Molecular Weight374.5
FormulaC18H26N6OS
Cas No.1402821-41-3
SmilesCCCn1cnc2c(NCc3ccc(C)s3)nc(N[C@H](CC)CO)nc12
Relative Density.1.33 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 90 mg/mL (240.32 mM), Sonication is recommended.
Methanol: 55 mg/mL (146.86 mM), Sonication is recommended.
Solution Preparation Table
Methanol/DMSO
1mg5mg10mg50mg
1 mM2.6702 mL13.3511 mL26.7023 mL133.5113 mL
5 mM0.5340 mL2.6702 mL5.3405 mL26.7023 mL
10 mM0.2670 mL1.3351 mL2.6702 mL13.3511 mL
20 mM0.1335 mL0.6676 mL1.3351 mL6.6756 mL
50 mM0.0534 mL0.2670 mL0.5340 mL2.6702 mL
100 mM0.0267 mL0.1335 mL0.2670 mL1.3351 mL

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